Tetraspanins in extracellular vesicle formation and function.
Tetraspanins in extracellular vesicle formation and function.
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DOI：
10.3389/fimmu.2014.00442
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发表时间：
2014
影响因子：
7.3
通讯作者：
Yáñez-Mó M
中科院分区：
文献类型：
--
作者：
Andreu Z;Yáñez-Mó M
细胞外囊泡（EVs）作为功能性膜蛋白、胞质蛋白、脂质和RNAs在细胞间转移的载体，代表了一种细胞间通讯的新机制。微囊泡、外泌体、脱落囊泡、微粒和外泌体是根据其来源、组成、大小和密度来指代不同类型EVs的最常见术语。外泌体起源于内体，由许多不同的细胞类型释放，参与不同的生理和/或病理过程。根据其来源，它们可以根据所传递的信息改变受体细胞的命运。在过去的二十年中，由于EVs可能被用作非侵入性生物标志物以及它们在生物工程和临床应用中的潜力，它们已成为许多研究的焦点。为了利用EVs的这种能力，应该解读其生物学的许多方面。在此，我们综述了EV生物发生、组装、特定蛋白质和遗传物质的募集机制，以及靶细胞的摄取机制，以努力理解EV的功能及其在临床应用中的效用。在这些背景下，将强调四跨膜蛋白超家族蛋白质的作用，它们是EVs中最丰富的膜蛋白之一。
Extracellular vesicles (EVs) represent a novel mechanism of intercellular communication as vehicles for intercellular transfer of functional membrane and cytosolic proteins, lipids, and RNAs. Microvesicles, ectosomes, shedding vesicles, microparticles, and exosomes are the most common terms to refer to the different kinds of EVs based on their origin, composition, size, and density. Exosomes have an endosomal origin and are released by many different cell types, participating in different physiological and/or pathological processes. Depending on their origin, they can alter the fate of recipient cells according to the information transferred. In the last two decades, EVs have become the focus of many studies because of their putative use as non-invasive biomarkers and their potential in bioengineering and clinical applications. In order to exploit this ability of EVs many aspects of their biology should be deciphered. Here, we review the mechanisms involved in EV biogenesis, assembly, recruitment of selected proteins, and genetic material as well as the uptake mechanisms by target cells in an effort to understand EV functions and their utility in clinical applications. In these contexts, the role of proteins from the tetraspanin superfamily, which are among the most abundant membrane proteins of EVs, will be highlighted.
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影响因子：
4
作者：
Chivet M;Hemming F;Pernet-Gallay K;Fraboulet S;Sadoul R
通讯作者：
Sadoul R
影响因子：
4.4
作者：
Arduise, Cecile;Abache, Toufik;Le Naour, Francoise
通讯作者：
Le Naour, Francoise
影响因子：
5.5
作者：
André, F;Scharz, NEC;Zitvogel, L
通讯作者：
Zitvogel, L
影响因子：
3.4
作者：
Cabezas, Sandra Columba;Federico, Maurizio
通讯作者：
Federico, Maurizio
DOI：
10.1083/jcb.200508014
发表时间：
2006-03-13
期刊：
The Journal of cell biology
影响因子：
--
作者：
Booth AM;Fang Y;Fallon JK;Yang JM;Hildreth JE;Gould SJ
通讯作者：
Gould SJ