Metabolomics in chronic pain research.
Metabolomics in chronic pain research.
复制标题
慢性疼痛研究中的代谢组学。
DOI：
10.1002/ejp.1677
复制
发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Curatolo M
中科院分区：
文献类型：
--
作者：
Teckchandani S;Nagana Gowda GA;Raftery D;Curatolo M
代谢组学涉及生物样品中小分子（代谢物）的识别和定量。由于代谢水平可以反映正常或改变的代谢途径，因此它们的测量可以提供信息来改善对疾病的理解、诊断和管理。尽管代谢组学潜力巨大，但其在疼痛研究中的应用却很少。本文介绍了当前的代谢组学技术，回顾了已发表的人类代谢组学疼痛研究，并比较了其他医学领域成功的代谢组学研究，目的是强调代谢组学为推进疼痛医学提供的机会。非系统审查。我们的检索确定了 19 项采用代谢组学方法的研究：纤维肌痛 (7)、慢性广泛性疼痛 (4)、其他肌肉骨骼疼痛 (5)、神经性疼痛 (1)、复杂区域疼痛综合征 (1) 和盆腔疼痛 (1)。这些研究使用了质谱或核磁共振。大多数的特点是样本量小。谷氨酸和睾酮代谢的改变以及肠道微生物组引起的代谢失衡存在一定的一致性。慢性疼痛的代谢组学研究尚处于起步阶段。大多数研究都处于试点阶段。代谢组学研究在医学的其他领域也取得了成功。这些成就应该激励研究人员扩大代谢组学研究，以提高对人类疼痛基本机制的理解，并提供诊断、预测和监测慢性疼痛状况的工具。代谢组学研究可以识别生物标志物，以支持治疗的开发和测试，从而促进个性化疼痛医学。
Metabolomics deals with the identification and quantification of small molecules (metabolites) in biological samples. As metabolite levels can reflect normal or altered metabolic pathways, their measurement provides information to improve the understanding, diagnosis and management of diseases. Despite its immense potential, metabolomics applications to pain research have been sparse. This paper describes current metabolomics techniques, reviews published human metabolomics pain research, and compares successful metabolomics research in other areas of medicine with the goal of highlighting opportunities offered by metabolomics to advance pain medicine. Non-systematic review. Our search identified 19 studies that adopted a metabolomics approach in: fibromyalgia (7), chronic widespread pain (4), other musculoskeletal pain conditions (5), neuropathic pain (1), complex regional pain syndrome (1) and pelvic pain (1). The studies used either mass spectrometry or nuclear magnetic resonance. Most are characterized by small sample sizes. Some consistency has been found for alterations in glutamate and testosterone metabolism, and metabolic imbalances caused by the gut microbiome. Metabolomics research in chronic pain is at its infancy. Most studies are at the pilot stage. Metabolomics research has been successful in other areas of medicine. These achievements should motivate investigators to expand metabolomics research to improve understanding of the basic mechanisms of human pain, as well as provide tools to diagnose, predict and monitor chronic pain conditions. Metabolomics research can lead to the identification of biomarkers to support the development and testing of treatments, thereby facilitating personalized pain medicine.
登录
查看更多内容
影响因子：
7.4
作者：
Gowda, G. A. Nagana;Gowda, Yashas N.;Raftery, Daniel
通讯作者：
Raftery, Daniel
影响因子：
4.6
作者：
Hadrévi J;Björklund M;Kosek E;Hällgren S;Antti H;Fahlström M;Hellström F
通讯作者：
Hellström F
影响因子：
4.2
作者：
Hackshaw, Kevin V.;Rodriguez-Saona, Luis;Buffington, C. A. Tony
通讯作者：
Buffington, C. A. Tony
影响因子：
4
作者：
Klyne, David M.;Moseley, G. Lorimer;Hodges, Paul W.
通讯作者：
Hodges, Paul W.
影响因子：
4
作者：
Gaskin, Darrell J.;Richard, Patrick
通讯作者：
Richard, Patrick