Resistance to oxidative stress shows low heritability and high common environmental variance in a wild bird
Resistance to oxidative stress shows low heritability and high common environmental variance in a wild bird
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野生鸟类对氧化应激的抵抗力表现出较低的遗传力和较高的常见环境差异
DOI：
10.1111/jeb.12454
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发表时间：
2014
影响因子：
2.1
通讯作者：
H. Richner
中科院分区：
文献类型：
--
作者：
Sylvain Losdat;Sylvain Losdat;F. Helfenstein;J. D. Blount;H. Richner
氧化应激最近被证明会影响几个与健康相关的特征，现在已经被公认为影响动物生活史进化的因素。然而，关于氧化应激的抗性在多大程度上是由遗传和环境效应决定的，以及它的进化潜力，特别是在野生种群中，人们知之甚少。此外，尽管具有重要的进化意义，但我们对表型性二型性和跨性别遗传在抵抗氧化应激中的相关性的了解仍然非常有限。在自由生活的大山雀(Parus Main)中，我们通过进行裂巢交叉培养实验，量化了后代对氧化应激的遗传力、共同环境效应、性别二型性和跨性别遗传相关性。对氧化应激的抵抗力是通过对脂质的氧化损伤和红细胞对受控自由基攻击的抵抗力来衡量的。氧化应激的两种测量方法都显示出低加性遗传差异、高共同环境效应和表型性别二型性，雄性对氧化应激表现出更高的抵抗力。跨性别的遗传相关性与统一性没有不同，我们发现在成年时对氧化应激的抵抗力没有实质性的遗传性，在第二年招募的39个人中进行了测量。我们的研究表明，个体抵抗氧化应激的能力主要受共同环境的影响，遗传力较低，因此进化潜力较低，至少在生命的早期阶段是这样。
Oxidative stress was recently demonstrated to affect several fitness‐related traits and is now well recognized to shape animal life‐history evolution. However, very little is known about how much resistance to oxidative stress is determined by genetic and environmental effects and hence about its potential for evolution, especially in wild populations. In addition, our knowledge of phenotypic sexual dimorphism and cross‐sex genetic correlations in resistance to oxidative stress remains extremely limited despite important evolutionary implications. In free‐living great tits (Parus major), we quantified heritability, common environmental effect, sexual dimorphism and cross‐sex genetic correlation in offspring resistance to oxidative stress by performing a split‐nest cross‐fostering experiment where 155 broods were split, and all siblings (n = 791) translocated and raised in two other nests. Resistance to oxidative stress was measured as both oxidative damage to lipids and erythrocyte resistance to a controlled free‐radical attack. Both measurements of oxidative stress showed low additive genetic variances, high common environmental effects and phenotypic sexual dimorphism with males showing a higher resistance to oxidative stress. Cross‐sex genetic correlations were not different from unity, and we found no substantial heritability in resistance to oxidative stress at adult age measured on 39 individuals that recruited the subsequent year. Our study shows that individual ability to resist to oxidative stress is primarily influenced by the common environment and has a low heritability with a consequent low potential for evolution, at least at an early stage of life.
影响因子：
7.4
作者：
Broedbaek, Kasper;Ribel-Madsen, Rasmus;Henriksen, Trine;Weimann, Allan;Petersen, Morten;Andersen, Jon T.;Afzal, Shoaib;Hjelvang, Brian;Roberts, L. Jackson, II;Vaag, Allan;Poulsen, Pernille;Poulsen, Henrik E.
通讯作者：
Poulsen, Henrik E.
DOI：
10.1073/pnas.90.19.8905
发表时间：
1993-10-01
影响因子：
11.1
作者：
LARSEN, PL
通讯作者：
LARSEN, PL