Neuroinflammation: the devil is in the details.
Neuroinflammation: the devil is in the details.
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DOI：
10.1111/jnc.13607
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发表时间：
2016-10
影响因子：
4.7
通讯作者：
Godbout JP
中科院分区：
文献类型：
--
作者：
DiSabato DJ;Quan N;Godbout JP
人们对了解脑和脊髓内的炎症反应非常感兴趣。集中在脑和脊髓内的炎症反应通常被称为“神经炎症”。神经炎症的方面在疾病、损伤、感染或应激的背景下变化。这些炎症反应的背景、过程和持续时间都是理解这些过程及其相应的生理、生化和行为后果的关键方面。小胶质细胞是中枢神经系统（CNS）的先天性免疫细胞，在介导这些神经炎症反应中起关键作用。由于神经炎症的内涵具有内在的负面性和不适应性，因此大多数研究集中在神经炎症的病理方面。然而，有几种程度的神经炎症反应，其中一些是积极的。在包括CNS损伤在内的许多情况下，存在影响功能恢复的炎症和内在修复过程的平衡。此外，还有其他几个例子，其中大脑和免疫系统之间的通信涉及有益和适应性的神经炎症过程。这篇评论的目的是区分不同的变化，在特定的方式和详细的神经炎症过程的积极和消极方面的神经炎症。
There is significant interest in understanding inflammatory responses within the brain and spinal cord. Inflammatory responses that are centralized within the brain and spinal cord are generally referred to as “neuroinflammatory”. Aspects of neuroinflammation vary within the context of disease, injury, infection or stress. The context, course, and duration of these inflammatory responses are all critical aspects in the understanding of these processes and their corresponding physiological, biochemical and behavioral consequences. Microglia, innate immune cells of the central nervous system (CNS), play key roles in mediating these neuroinflammatory responses. Because the connotation of neuroinflammation is inherently negative and maladaptive, the majority of research focus is on the pathological aspects of neuroinflammation. There are, however, several degrees of neuroinflammatory responses, some of which are positive. In many circumstances including CNS injury, there is a balance of inflammatory and intrinsic repair processes that influences functional recovery. In addition, there are several other examples where communication between the brain and immune system involves neuroinflammatory processes that are beneficial and adaptive. The purpose of this review is to distinguish different variations of neuroinflammation in a context-specific manner and detail both positive and negative aspects of neuroinflammatory processes.
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DOI：
10.1523/jneurosci.5399-12.2013
发表时间：
2013-04-03
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bachstetter AD;Rowe RK;Kaneko M;Goulding D;Lifshitz J;Van Eldik LJ
通讯作者：
Van Eldik LJ
影响因子：
9.3
作者：
Bachstetter, Adam D.;Xing, Bin;Van Eldik, Linda J.
通讯作者：
Van Eldik, Linda J.
影响因子：
15.1
作者：
Barrientos, Ruth M.;Watkins, Linda R.;Rudy, Jerry W.;Maier, Steven F.
通讯作者：
Maier, Steven F.
影响因子：
1.7
作者：
Borowski, T;Kokkinidis, E;Anisman, H
通讯作者：
Anisman, H
影响因子：
5.3
作者：
Barrette, Benoit;Hebert, Marc-Andre;Lacroix, Steve
通讯作者：
Lacroix, Steve