Application of Radiosensitizers in Cancer Radiotherapy.
Application of Radiosensitizers in Cancer Radiotherapy.
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DOI：
10.2147/ijn.s290438
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发表时间：
2021
影响因子：
8
通讯作者：
Han S
中科院分区：
文献类型：
--
作者：
Gong L;Zhang Y;Liu C;Zhang M;Han S
放射治疗（RT）是一种使用高剂量辐射杀死癌细胞和缩小肿瘤的癌症治疗方法。虽然放射治疗已经取得了巨大的成功，但如何增强放射治疗对肿瘤组织的损伤，减少对健康组织的副作用，仍然是一个棘手的挑战。放射增敏剂是一种化学物质或药物，通过加速DNA损伤和间接产生自由基来增强对肿瘤细胞的杀伤作用。在大多数情况下，放射致敏剂对正常组织的影响较小。近年来，已经开发了几种策略来开发高效低毒的放射增敏剂。本文首先综述了放射性增敏剂的应用，包括小分子、大分子和纳米材料，特别是在临床试验中的应用。其次，综述了放射性增敏剂的发展现状和提高其敏感性的可能机制。第三，介绍了放射增敏剂在肿瘤治疗中的临床转化所面临的挑战和前景。
Radiotherapy (RT) is a cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumors. Although great success has been achieved on radiotherapy, there is still an intractable challenge to enhance radiation damage to tumor tissue and reduce side effects to healthy tissue. Radiosensitizers are chemicals or pharmaceutical agents that can enhance the killing effect on tumor cells by accelerating DNA damage and producing free radicals indirectly. In most cases, radiosensitizers have less effect on normal tissues. In recent years, several strategies have been exploited to develop radiosensitizers that are highly effective and have low toxicity. In this review, we first summarized the applications of radiosensitizers including small molecules, macromolecules, and nanomaterials, especially those that have been used in clinical trials. Second, the development states of radiosensitizers and the possible mechanisms to improve radiosensitizers sensibility are reviewed. Third, the challenges and prospects for clinical translation of radiosensitizers in oncotherapy are presented.
影响因子：
5.5
作者：
Mardare AI;Mardare CC;Kollender JP;Huber S;Hassel AW
通讯作者：
Hassel AW