Absolute lymphocyte count is associated with survival in ovarian cancer independent of tumor-infiltrating lymphocytes.
Absolute lymphocyte count is associated with survival in ovarian cancer independent of tumor-infiltrating lymphocytes.
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DOI：
10.1186/1479-5876-10-33
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发表时间：
2012-02-27
影响因子：
7.4
通讯作者：
Nelson BH
中科院分区：
文献类型：
--
作者：
Milne K;Alexander C;Webb JR;Sun W;Dillon K;Kalloger SE;Gilks CB;Clarke B;Köbel M;Nelson BH
免疫系统强烈影响卵巢癌患者的预后。特别是，外周血中的淋巴细胞绝对计数（ALC）和肿瘤浸润淋巴细胞（TIL）的存在均与良好的预后相关。然而，ALC，TIL和预后之间的机制关系知之甚少。我们假设高ALC值可能与更强的肿瘤免疫相关，表现为TIL增加，肿瘤负荷降低和生存期延长。从高级别浆液性卵巢癌（HGSC）初次治疗前、治疗期间或治疗后≥ 2年的患者记录中收集ALC值。采用流式细胞术检测外周血淋巴细胞亚群。免疫组化检测CD8+和CD20+ TIL。总体而言，患者在诊断HGSC前两年或两年以上具有正常ALC值。这些值不能预测疾病的严重程度或HGSC后续发展后的生存率。相反，ALC随着HGSC的发展而下降，与疾病负担成比例。这种下降涉及所有淋巴细胞亚群。手术后ALC增加，化疗期间保持稳定，但很少恢复到诊断前水平。诊断时记录的ALC值与CD8+或CD20+ TIL无关，但与无进展生存期相关。具有高固有ALC值的患者在随后发展为HGSC时没有显示出临床或生存优势。诊断时的ALC值是预后性的，因为它与疾病负荷相关，而不是与TIL相关。ALC的治疗增强可能是必要的，但不足以改善HGSC的生存。
The immune system strongly influences outcome in patients with ovarian cancer. In particular, the absolute lymphocyte count in peripheral blood (ALC) and the presence of tumor-infiltrating lymphocytes (TIL) have each been associated with favourable prognosis. However, the mechanistic relationships between ALC, TIL and prognosis are poorly understood. We hypothesized that high ALC values might be associated with stronger tumor immunity as manifested by increased TIL, decreased tumor burden and longer survival. ALC values were collected from patient records ≥ 2 years before, during or after primary treatment for high-grade serous ovarian cancer (HGSC). Lymphocyte subsets were assessed in peripheral blood by flow cytometry. CD8+ and CD20+ TIL were assessed by immunohistochemistry. Overall, patients had normal ALC values two or more years prior to diagnosis of HGSC. These values were not predictive of disease severity or survival upon subsequent development of HGSC. Rather, ALC declined upon development of HGSC in proportion to disease burden. This decline involved all lymphocyte subsets. ALC increased following surgery, remained stable during chemotherapy, but rarely recovered to pre-diagnostic levels. ALC values recorded at diagnosis did not correlate with CD8+ or CD20+ TIL but were associated with progression-free survival. Patients with high intrinsic ALC values show no clinical or survival advantage upon subsequent development of HGSC. ALC values at diagnosis are prognostic due to an association with disease burden rather than TIL. Therapeutic enhancement of ALC may be necessary but not sufficient to improve survival in HGSC.
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DOI：
10.1093/jnci/djp438
发表时间：
2010-01-06
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Anderson GL;McIntosh M;Wu L;Barnett M;Goodman G;Thorpe JD;Bergan L;Thornquist MD;Scholler N;Kim N;O'Briant K;Drescher C;Urban N
通讯作者：
Urban N
影响因子：
3.9
作者：
Fumagalli, LA;Vinke, J;Nespoli, A
通讯作者：
Nespoli, A
影响因子：
5.8
作者：
Cho, HanByoul;Hur, Hye Won;Lee, Kook
通讯作者：
Lee, Kook
影响因子：
2
作者：
Lissoni, P;Brivio, F;Gardani, GS
通讯作者：
Gardani, GS
DOI：
10.1111/j.1532-5415.1986.tb04906.x
发表时间：
1986-09-01
影响因子：
6.3
作者：
BENDER, BS;NAGEL, JE;ANDRES, R
通讯作者：
ANDRES, R