Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death.
Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death.
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DOI：
10.1038/cddis.2009.11
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发表时间：
2010
影响因子：
9
通讯作者：
中科院分区：
文献类型：
--
作者：
嘌呤能信号系统，它使用嘌呤和嘧啶作为化学递质，并作为效应器的嘌呤受体，深深植根于进化和发展，是细胞通讯的关键因素。ATP及其衍生物在最原始的生命形式中起着“危险信号”的作用。嘌呤受体广泛分布于所有细胞和组织中，参与调节更多的生物过程。除了在神经传递、神经调节和分泌中的快速嘌呤能信号传导之外，在身体的大多数系统的发育和再生中存在涉及细胞增殖、分化、运动和死亡的长期（营养）嘌呤能信号传导。在这篇文章中，我们专注于后者在免疫/防御系统，在复层上皮在内脏器官和皮肤，胚胎发育，骨形成和再吸收，以及在癌症。
The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development and is a pivotal factor in cell communication. The ATP and its derivatives function as a ‘danger signal' in the most primitive forms of life. Purinoceptors are extraordinarily widely distributed in all cell types and tissues and they are involved in the regulation of an even more extraordinary number of biological processes. In addition to fast purinergic signalling in neurotransmission, neuromodulation and secretion, there is long-term (trophic) purinergic signalling involving cell proliferation, differentiation, motility and death in the development and regeneration of most systems of the body. In this article, we focus on the latter in the immune/defence system, in stratified epithelia in visceral organs and skin, embryological development, bone formation and resorption, as well as in cancer.
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影响因子：
3.3
作者：
ABBRACCHIO, MP;SAFFREY, MJ;BURNSTOCK, G
通讯作者：
BURNSTOCK, G
影响因子：
3.6
作者：
Bar, Isabelle;Guns, Pieter-Jan;Robaye, Bernard
通讯作者：
Robaye, Bernard
P2受体在神经胶质细胞中的作用：关注星形胶质细胞。
影响因子：
3.5
作者：
Abbracchio, Maria P;Ceruti, Stefania
通讯作者：
Ceruti, Stefania
影响因子：
7.3
作者：
BURNSTOCK, G;CAMPBELL, G;SMYTHE, A
通讯作者：
SMYTHE, A
DOI：
10.1152/ajpregu.00470.2001
发表时间：
2001-11-01
影响因子：
2.8
作者：
Brown, R;Ollerstam, A;Persson, AEG
通讯作者：
Persson, AEG