Cell augmentation strategies for cardiac stem cell therapies.
Cell augmentation strategies for cardiac stem cell therapies.
复制标题
心脏干细胞疗法的细胞增强策略。
DOI：
10.1002/sctm.20-0489
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发表时间：
2021-06
影响因子：
6
通讯作者：
Perriman A
中科院分区：
文献类型：
--
作者：
Cruz-Samperio R;Jordan M;Perriman A
心肌梗死（MI）已成为发达国家的主要死亡原因，给社会带来了重大的心理和经济负担。目前对急性MI的治疗是针对快速恢复灌注以限制对心肌的损伤，而不是促进组织再生和随后的收缩功能恢复。再生细胞疗法（CT），特别是那些使用多能干细胞（SC）的疗法，是MI后治疗的焦点。不幸的是，CT的疗效受到其长期存活率、归巢和心肌植入不良的限制。作为回应，一系列新的基于SC的技术正在开发中，以提供额外的细胞模式，使CT更接近临床。在这篇综述中，讨论了目前新兴CT的现状及其用于MI后治疗的增强策略。在此过程中，我们强调了最近的进展，通过基因修饰，重组蛋白的固定化，并利用软仿生支架接口的细胞膜再造。 在这篇简要的综述中，我们讨论了心血管干细胞治疗的新兴细胞扩增策略。特别是，我们强调了通过遗传修饰，重组蛋白固定化和利用软仿生支架界面进行细胞膜再工程的最新进展。
Myocardial infarction (MI) has been the primary cause of death in developed countries, resulting in a major psychological and financial burden for society. Current treatments for acute MI are directed toward rapid restoration of perfusion to limit damage to the myocardium, rather than promoting tissue regeneration and subsequent contractile function recovery. Regenerative cell therapies (CTs), in particular those using multipotent stem cells (SCs), are in the spotlight for treatment post‐MI. Unfortunately, the efficacy of CTs is somewhat limited by their poor long‐term viability, homing, and engraftment to the myocardium. In response, a range of novel SC‐based technologies are in development to provide additional cellular modalities, bringing CTs a step closer to the clinic. In this review, the current landscape of emerging CTs and their augmentation strategies for the treatment post‐MI are discussed. In doing so, we highlight recent advances in cell membrane reengineering via genetic modifications, recombinant protein immobilization, and the utilization of soft biomimetic scaffold interfaces. In this concise review, the landscape of emerging cell augmentation strategies for cardiovascular stem cell therapies are discussed. In particular, we highlight recent advances in cell membrane re‐engineering via genetic modifications, recombinant protein immobilization, and the utilization of soft biomimetic scaffold interfaces.
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影响因子：
14
作者：
Cheng, Hao;Byrska-Bishop, Marta;Zhang, Cathy T.;Kastrup, Christian J.;Hwang, Nathaniel S.;Tai, Albert K.;Lee, Won Woo;Xu, Xiaoyang;Nahrendorf, Matthias;Langer, Robert;Anderson, Daniel G.
通讯作者：
Anderson, Daniel G.
影响因子：
37.8
作者：
Barbash, IM;Chouraqui, P;Leor, J
通讯作者：
Leor, J
影响因子：
20.1
作者：
Banerjee MN;Bolli R;Hare JM
通讯作者：
Hare JM
心血管治疗诊断中的细胞外囊泡
影响因子：
12.4
作者：
Bei Y;Das S;Rodosthenous RS;Holvoet P;Vanhaverbeke M;Monteiro MC;Monteiro VVS;Radosinska J;Bartekova M;Jansen F;Li Q;Rajasingh J;Xiao J
通讯作者：
Xiao J
影响因子：
16.6
作者：
Armstrong JPK;Shakur R;Horne JP;Dickinson SC;Armstrong CT;Lau K;Kadiwala J;Lowe R;Seddon A;Mann S;Anderson JLR;Perriman AW;Hollander AP
通讯作者：
Hollander AP