Extracellular Vesicles in Cardiovascular Theranostics.
Extracellular Vesicles in Cardiovascular Theranostics.
复制标题
心血管治疗诊断中的细胞外囊泡
作者：
Bei Y;Das S;Rodosthenous RS;Holvoet P;Vanhaverbeke M;Monteiro MC;Monteiro VVS;Radosinska J;Bartekova M;Jansen F;Li Q;Rajasingh J;Xiao J
细胞外囊泡（EV）是小的双层脂质膜囊泡，其可以由大多数细胞类型释放并在大多数体液中检测到。EV通过将其生物活性物质转移到受体细胞或激活靶细胞中的信号通路来发挥细胞间通讯的关键功能。越来越多的证据表明EV在心血管疾病（CVD）中具有重要的调节作用。由心肌细胞、内皮细胞、成纤维细胞和干细胞分泌的EV在与CVD相关的病理生理过程中起重要作用，所述病理生理过程例如心脏肥大、心肌细胞存活和凋亡、心脏纤维化和血管生成。在这篇综述中，我们将首先概述目前的知识有关的物理特性，生物学内容，和分离方法的EV。然后，我们将重点介绍心血管EV的功能作用及其在CVD中的病理生理学作用，并总结EV作为CVD治疗剂和生物标志物的潜力。最后，我们将讨论电动汽车作为一种新型药物输送系统的具体应用和电动汽车在再生医学领域的效用。
Extracellular vesicles (EVs) are small bilayer lipid membrane vesicles that can be released by most cell types and detected in most body fluids. EVs exert key functions for intercellular communication via transferring their bioactive cargos to recipient cells or activating signaling pathways in target cells. Increasing evidence has shown the important regulatory effects of EVs in cardiovascular diseases (CVDs). EVs secreted by cardiomyocytes, endothelial cells, fibroblasts, and stem cells play essential roles in pathophysiological processes such as cardiac hypertrophy, cardiomyocyte survival and apoptosis, cardiac fibrosis, and angiogenesis in relation to CVDs. In this review, we will first outline the current knowledge about the physical characteristics, biological contents, and isolation methods of EVs. We will then focus on the functional roles of cardiovascular EVs and their pathophysiological effects in CVDs, as well as summarize the potential of EVs as therapeutic agents and biomarkers for CVDs. Finally, we will discuss the specific application of EVs as a novel drug delivery system and the utility of EVs in the field of regenerative medicine.
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人骨髓间充质干细胞来源的细胞外囊泡促进大鼠心肌梗死模型中的血管生成
影响因子：
4.7
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1.2
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Arslan, Fatih;Lai, Ruenn Chai;de Kleijn, Dominique P.
通讯作者：
de Kleijn, Dominique P.
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15.9
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Blin, Guillaume;Nury, David;Puceat, Michel
通讯作者：
Puceat, Michel