Promotion of Poststroke Motor-Function Recovery with Repetitive Transcranial Magnetic Stimulation by Regulating the Interhemispheric Imbalance.

Promotion of Poststroke Motor-Function Recovery with Repetitive Transcranial Magnetic Stimulation by Regulating the Interhemispheric Imbalance.
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通过调节大脑半球间不平衡,重复经颅磁刺激促进中风后运动功能恢复

DOI:
10.3390/brainsci10090648
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发表时间:
2020-09-18
期刊:
影响因子:
3.3
通讯作者:
Jiang C
Jiang C
中科院分区:
医学4区
文献类型:
--
作者:
Yuan X;Yang Y;Cao N;Jiang C

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相似文献

重复经颅磁刺激(rTMS)是一种非侵入性脑刺激技术,可瞬时调节大脑皮层兴奋性,在卒中后运动功能恢复方面取得总体积极成果。对侧未受影响半球对同侧受影响半球的过度抑制严重阻碍了卒中后运动功能的恢复。因此,皮质内去抑制可以作为一种方法来管理中风后脑损伤。这项技术促进神经可塑性,以更快地恢复运动功能。rTMS通过调节半球间的不平衡抑制来解除脑功能的单侧抑制。本文总结了2016年至今的12项研究,重点关注rTMS通过调节抑制性输入的半球间失衡对急性和慢性卒中后运动功能的影响。虽然rTMS研究显示了对脑卒中患者运动功能恢复的良好结果,但不同的干预方法可能导致结果差异。不能常规使用统一的最佳刺激模型,主要是由于研究中的刺激方案、卒中类型和结局测量差异。因此,应进一步研究rTMS对卒中后运动功能恢复的影响,以标准化rTMS程序,实现卒中后运动功能的最佳恢复。需要更多的随机、安慰剂对照临床试验和标准化的rTMS方案,以确保治疗的有效性。
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain-stimulation technique that transiently modulates cerebral cortex excitability, achieving overall positive results in poststroke motor-function recovery. Excessive inhibition of the ipsilesional-affected hemisphere by the contralesional-unaffected hemisphere has seriously hindered poststroke motor-function recovery. Hence, intracortical disinhibition can be used as an approach to managing poststroke brain injury. This technique promotes neural plasticity for faster motor-function recovery. rTMS relieves unilateral inhibition of the brain function by regulatinga interhemispheric-imbalanced inhibition. This paper summarized 12 studies from 2016 to date, focusing on rTMS on motor function after acute and chronic stroke by regulating the interhemispheric imbalance of inhibitory inputs. Although rTMS studies have shown promising outcomes on recovery of motor functions in stroke patients, different intervention methods may lead to discrepancies in results. A uniform optimal stimulus model cannot routinely be used, mainly due to the stimulus schemes, stroke types and outcome-measuring differences among studies. Thus, the effect of rTMS on poststroke motor-function recovery should be investigated further to standardize the rTMS program for optimal poststroke motor-function recovery. More randomized, placebo-controlled clinical trials with standardized rTMS protocols are needed to ensure the effectiveness of the treatment.
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影响因子: 4.2
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