Compensatory functional connectome changes in a rat model of traumatic brain injury.
Compensatory functional connectome changes in a rat model of traumatic brain injury.
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外伤性脑损伤大鼠模型代偿功能连接体的变化。
DOI：
10.1093/braincomms/fcab244
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发表时间：
2021
影响因子：
4.8
通讯作者：
Febo M
中科院分区：
文献类型：
--
作者：
Yang Z;Zhu T;Pompilus M;Fu Y;Zhu J;Arjona K;Arja RD;Grudny MM;Plant HD;Bose P;Wang KK;Febo M
穿透性皮质撞击损伤改变了损伤中心以外涉及情感、感觉运动和认知处理的区域的神经元通讯。了解创伤性脑损伤如何重组局部和全脑节点相互作用可能为监测病理进展和恢复提供有价值的定量参数。为此，我们研究了在持续受控皮质冲击的大鼠中在 11.1 T 下获得的功能 MRI 信号的自发波动，并在损伤后 2 天和 30 天进行成像。基于图论的计算应用于由来自 162 个区域的功能 MRI 信号之间的 12 879 个成对相关性构建的加权无向矩阵。我们的数据表明，在控制皮质影响后的第 2 天和第 30 天，位于对侧皮质、丘脑和基底前脑区域的节点的连接强度显着增加。受伤后第 2 天成像的大鼠的网络模块化程度明显高于对照组，有影响力的节点（具有高特征向量中心性）包含在对侧模块内，并且较少参与跨模块交互。到第 30 天，模块性和跨模块交互恢复，尽管同侧皮层中仍保留着一组具有低强度和低特征向量中心性的节点。我们的结果表明，节点强度、模块性、特征向量中心性和参与系数的变化追踪了早期和晚期创伤性脑损伤对大脑功能连接的影响。我们认为，观察到的针对受控皮质影响的补偿性功能连接重组可能不利于损伤后早期的全脑通讯。杨等人。在创伤性脑损伤的大鼠模型中使用功能磁共振成像和图论分析，并报告网络拓扑的变化，跟踪早期和晚期创伤性脑损伤对功能连接的影响。观察到的变化强调了功能磁共振成像活动模式不利于损伤后早期的沟通。
Penetrating cortical impact injuries alter neuronal communication beyond the injury epicentre, across regions involved in affective, sensorimotor and cognitive processing. Understanding how traumatic brain injury reorganizes local and brain wide nodal interactions may provide valuable quantitative parameters for monitoring pathological progression and recovery. To this end, we investigated spontaneous fluctuations in the functional MRI signal obtained at 11.1 T in rats sustaining controlled cortical impact and imaged at 2- and 30-days post-injury. Graph theory-based calculations were applied to weighted undirected matrices constructed from 12 879 pairwise correlations between functional MRI signals from 162 regions. Our data indicate that on Days 2 and 30 post-controlled cortical impact there is a significant increase in connectivity strength in nodes located in contralesional cortical, thalamic and basal forebrain areas. Rats imaged on Day 2 post-injury had significantly greater network modularity than controls, with influential nodes (with high eigenvector centrality) contained within the contralesional module and participating less in cross-modular interactions. By Day 30, modularity and cross-modular interactions recover, although a cluster of nodes with low strength and low eigenvector centrality remain in the ipsilateral cortex. Our results suggest that changes in node strength, modularity, eigenvector centrality and participation coefficient track early and late traumatic brain injury effects on brain functional connectivity. We propose that the observed compensatory functional connectivity reorganization in response to controlled cortical impact may be unfavourable to brain wide communication in the early post-injury period. Yang et al. used functional magnetic resonance imaging and graph theory analysis in a rat model of traumatic brain injury and report changes in network topology that tracked early and late traumatic brain injury effects on functional connectivity. The observed changes emphasize functional magnetic resonance imaging activity patterns unfavourable to communication in the early post-injury period.
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DOI：
10.1093/brain/awx309
发表时间：
2018-01-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
De Simoni S;Jenkins PO;Bourke NJ;Fleminger JJ;Hellyer PJ;Jolly AE;Patel MC;Cole JH;Leech R;Sharp DJ
通讯作者：
Sharp DJ
影响因子：
4.2
作者：
Hall, Edward D.;Bryant, Ying Deng;Sullivan, Patrick G.
通讯作者：
Sullivan, Patrick G.
影响因子：
3.7
作者：
Gómez-Gardeñes J;Zamora-López G;Moreno Y;Arenas A
通讯作者：
Arenas A
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.7
作者：
Groppe DM;Urbach TP;Kutas M
通讯作者：
Kutas M