Altered caudate connectivity is associated with executive dysfunction after traumatic brain injury.
Altered caudate connectivity is associated with executive dysfunction after traumatic brain injury.
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DOI：
10.1093/brain/awx309
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Sharp DJ
中科院分区：
文献类型：
--
作者：
De Simoni S;Jenkins PO;Bourke NJ;Fleminger JJ;Hellyer PJ;Jolly AE;Patel MC;Cole JH;Leech R;Sharp DJ
Traumatic brain injury often produces executive dysfunction, causing long-term problems with behaviour and personality. De Simoni et al. report that executive dysfunction following TBI is associated with altered corticostriatal interactions important for behavioural control. These findings provide a target for the evaluation of treatments aimed at improving executive function after TBI. Traumatic brain injury often produces executive dysfunction. This characteristic cognitive impairment often causes long-term problems with behaviour and personality. Frontal lobe injuries are associated with executive dysfunction, but it is unclear how these injuries relate to corticostriatal interactions that are known to play an important role in behavioural control. We hypothesized that executive dysfunction after traumatic brain injury would be associated with abnormal corticostriatal interactions, a question that has not previously been investigated. We used structural and functional MRI measures of connectivity to investigate this. Corticostriatal functional connectivity in healthy individuals was initially defined using a data-driven approach. A constrained independent component analysis approach was applied in 100 healthy adult dataset from the Human Connectome Project. Diffusion tractography was also performed to generate white matter tracts. The output of this analysis was used to compare corticostriatal functional connectivity and structural integrity between groups of 42 patients with traumatic brain injury and 21 age-matched controls. Subdivisions of the caudate and putamen had distinct patterns of functional connectivity. Traumatic brain injury patients showed disruption to functional connectivity between the caudate and a distributed set of cortical regions, including the anterior cingulate cortex. Cognitive impairments in the patients were mainly seen in processing speed and executive function, as well as increased levels of apathy and fatigue. Abnormalities of caudate functional connectivity correlated with these cognitive impairments, with reductions in right caudate connectivity associated with increased executive dysfunction, information processing speed and memory impairment. Structural connectivity, measured using diffusion tensor imaging between the caudate and anterior cingulate cortex was impaired and this also correlated with measures of executive dysfunction. We show for the first time that altered subcortical connectivity is associated with large-scale network disruption in traumatic brain injury and that this disruption is related to the cognitive impairments seen in these patients.
Traumatic brain injury often produces executive dysfunction, causing long-term problems with behaviour and personality. De Simoni et al. report that executive dysfunction following TBI is associated with altered corticostriatal interactions important for behavioural control. These findings provide a target for the evaluation of treatments aimed at improving executive function after TBI. Traumatic brain injury often produces executive dysfunction. This characteristic cognitive impairment often causes long-term problems with behaviour and personality. Frontal lobe injuries are associated with executive dysfunction, but it is unclear how these injuries relate to corticostriatal interactions that are known to play an important role in behavioural control. We hypothesized that executive dysfunction after traumatic brain injury would be associated with abnormal corticostriatal interactions, a question that has not previously been investigated. We used structural and functional MRI measures of connectivity to investigate this. Corticostriatal functional connectivity in healthy individuals was initially defined using a data-driven approach. A constrained independent component analysis approach was applied in 100 healthy adult dataset from the Human Connectome Project. Diffusion tractography was also performed to generate white matter tracts. The output of this analysis was used to compare corticostriatal functional connectivity and structural integrity between groups of 42 patients with traumatic brain injury and 21 age-matched controls. Subdivisions of the caudate and putamen had distinct patterns of functional connectivity. Traumatic brain injury patients showed disruption to functional connectivity between the caudate and a distributed set of cortical regions, including the anterior cingulate cortex. Cognitive impairments in the patients were mainly seen in processing speed and executive function, as well as increased levels of apathy and fatigue. Abnormalities of caudate functional connectivity correlated with these cognitive impairments, with reductions in right caudate connectivity associated with increased executive dysfunction, information processing speed and memory impairment. Structural connectivity, measured using diffusion tensor imaging between the caudate and anterior cingulate cortex was impaired and this also correlated with measures of executive dysfunction. We show for the first time that altered subcortical connectivity is associated with large-scale network disruption in traumatic brain injury and that this disruption is related to the cognitive impairments seen in these patients.
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影响因子：
5.3
作者：
Bonnelle, Valerie;Leech, Robert;Sharp, David J.
通讯作者：
Sharp, David J.
影响因子：
56.9
作者：
DAMASIO, H;GRABOWSKI, T;DAMASIO, AR
通讯作者：
DAMASIO, AR
DOI：
10.1097/00004583-199703000-00016
发表时间：
1997-03-01
影响因子：
13.3
作者：
Casey, BJ;Castellanos, FX;Rapoport, JL
通讯作者：
Rapoport, JL
影响因子：
3
作者：
Barnes KA;Cohen AL;Power JD;Nelson SM;Dosenbach YB;Miezin FM;Petersen SE;Schlaggar BL
通讯作者：
Schlaggar BL
影响因子：
2.4
作者：
Draper, Kristy;Ponsford, Jennie
通讯作者：
Ponsford, Jennie