Contralateral dissociation between neural activity and cerebral blood volume during recurrent acute focal neocortical seizures.
Contralateral dissociation between neural activity and cerebral blood volume during recurrent acute focal neocortical seizures.
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DOI：
10.1111/epi.12726
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发表时间：
2014-09
期刊：
影响因子：
5.6
通讯作者：
Berwick J
中科院分区：
文献类型：
--
作者：
Harris S;Boorman L;Bruyns-Haylett M;Kennerley A;Ma H;Zhao M;Overton PG;Schwartz TH;Berwick J
癫痫事件是否局部或远程破坏正常的神经血管耦合机制尚不清楚。我们试图研究局灶性新皮层癫痫急性模型中的神经血管耦合，包括癫痫发作区和对侧同位皮层。在4-氨基吡啶（4-AP，15 mm，1 μl）反复诱发的局灶性癫痫发作中，观察了同侧和对侧触须皮质的神经血管耦联。局部场电位（LFP）和多单位尖峰活动（MUA）通过两个双边植入16通道微电极记录。并行二维光学成像光谱被用来产生脑血容量（CBV）的时空地图。右侧触须皮质（RVC）的复发性急性癫痫发作产生了同侧LFP和MUA活性的显著增加，最显著的是在第5层，与CBV的局部增加呈非线性相关。与此相反，对侧左触须皮质（LVC）表现出相对较小的非层状神经活动的具体增加加上CBV的减少，表明神经和血流动力学反应之间的分离。这些发现提供了深入了解癫痫事件对神经血管单位的影响，并具有重要的意义，无论是在疾病的灌注成像信号的解释和理解癫痫的广泛影响。
Whether epileptic events disrupt normal neurovascular coupling mechanisms locally or remotely is unclear. We sought to investigate neurovascular coupling in an acute model of focal neocortical epilepsy, both within the seizure onset zone and in contralateral homotopic cortex. Neurovascular coupling in both ipsilateral and contralateral vibrissal cortices of the urethane-anesthetized rat were examined during recurrent 4-aminopyridine (4-AP, 15 mm, 1 μl) induced focal seizures. Local field potential (LFP) and multiunit spiking activity (MUA) were recorded via two bilaterally implanted 16-channel microelectrodes. Concurrent two-dimensional optical imaging spectroscopy was used to produce spatiotemporal maps of cerebral blood volume (CBV). Recurrent acute seizures in right vibrissal cortex (RVC) produced robust ipsilateral increases in LFP and MUA activity, most prominently in layer 5, that were nonlinearly correlated to local increases in CBV. In contrast, contralateral left vibrissal cortex (LVC) exhibited relatively smaller nonlaminar specific increases in neural activity coupled with a decrease in CBV, suggestive of dissociation between neural and hemodynamic responses. These findings provide insights into the impact of epileptic events on the neurovascular unit, and have important implications both for the interpretation of perfusion-based imaging signals in the disorder and understanding the widespread effects of epilepsy.
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影响因子：
16.2
作者：
Goense J;Merkle H;Logothetis NK
通讯作者：
Logothetis NK
影响因子：
3.8
作者：
Borbély, S;Halasy, K;Világi, I
通讯作者：
Világi, I
DOI：
10.1097/00004647-200208000-00002
发表时间：
2002-08-01
影响因子：
6.3
作者：
Harel, N;Lee, SP;Kim, SG
通讯作者：
Kim, SG
影响因子：
11.1
作者：
del Zoppo GJ
通讯作者：
del Zoppo GJ
影响因子：
3.3
作者：
Kennerley, AJ;Berwick, J;Mayhew, JE
通讯作者：
Mayhew, JE