Development of very large electrode arrays for epiretinal stimulation (VLARS)
Development of very large electrode arrays for epiretinal stimulation (VLARS)
复制标题
开发用于视网膜前刺激的超大电极阵列（VLARS）
DOI：
--
复制
发表时间：
2014
影响因子：
3.9
通讯作者：
G. Roessler
中科院分区：
文献类型：
--
作者：
Florian Waschkowski;Stephan Hesse;Anne Christine Rieck;T. Lohmann;C. Brockmann;T. Laube;N. Bornfeld;G. Thumann;P. Walter;W. Mokwa;S. Johnen;G. Roessler
视网膜植入物已经被开发用于治疗导致视网膜变性的失明，例如视网膜色素变性（RP）。视网膜刺激器只覆盖视网膜的一小部分，通常在其中心。为了不仅恢复中心视力，而且恢复有用的视野，视网膜刺激器需要覆盖视网膜的更大区域。然而，大面积视网膜刺激器更难以植入眼睛中。关于这一挑战的一些基本问题应该在一系列实验中得到回答。大面积视网膜刺激器被制造为柔性多电极阵列（MEA）使用硅技术与聚酰亚胺作为基板的基本材料。电极由覆盖有反应溅射的氧化铱的金制成。考虑了几种原型设计，并将其植入摘除的猪眼中。原型多边环境协定也被用作记录装置。制作了直径为12 mm的大面积视网膜刺激器MEA，在正常视力的人眼中覆盖37.6°的视角。该结构足够柔韧，可以通过插入喷嘴以折叠状态植入。植入物可以放置在视网膜表面并使用视网膜钉固定在这里。使用这些装置可以在体外记录视网膜神经元的自发活动。大的柔性膜电极覆盖更广泛的区域的视网膜作为当前的设备可以使用硅技术与聚酰亚胺作为基础材料制造。建立了将这种大型装置插入眼睛的主要外科技术，并且该装置还可用于记录视网膜神经活动。
Retinal implants have been developed to treat blindness causing retinal degenerations such as Retinitis pigmentosa (RP). The retinal stimulators are covering only a small portion of the retina usually in its center. To restore not only central vision but also a useful visual field retinal stimulators need to cover a larger area of the retina. However, large area retinal stimulators are much more difficult to implant into an eye. Some basic questions concerning this challenge should be answered in a series of experiments. Large area retinal stimulators were fabricated as flexible multielectrode arrays (MEAs) using silicon technology with polyimide as the basic material for the substrate. Electrodes were made of gold covered with reactively sputtered iridium oxide. Several prototype designs were considered and implanted into enucleated porcine eyes. The prototype MEAs were also used as recording devices. Large area retinal stimulator MEAs were fabricated with a diameter of 12 mm covering a visual angle of 37.6° in a normal sighted human eye. The structures were flexible enough to be implanted in a folded state through an insertion nozzle. The implants could be positioned onto the retinal surface and fixated here using a retinal tack. Recording of spontaneous activity of retinal neurons was possible in vitro using these devices. Large flexible MEAs covering a wider area of the retina as current devices could be fabricated using silicon technology with polyimide as a base material. Principal surgical techniques were established to insert such large devices into an eye and the devices could also be used for recording of retinal neural activity.
登录
查看更多内容
影响因子：
3
作者：
Ahuja, A. K.;Yeoh, J.;daCruz, L.
通讯作者：
daCruz, L.
影响因子：
2.5
作者：
Fried, Shelley I.;Lasker, Aaron C. W.;Rizzo, Joseph F., III
通讯作者：
Rizzo, Joseph F., III
影响因子：
--
作者：
Daiger, Stephen P.;Bowne, Sara J.;Sullivan, Lori S.
通讯作者：
Sullivan, Lori S.
影响因子：
4.2
作者：
BUNKER, CH;BERSON, EL;RODERICK, TH
通讯作者：
RODERICK, TH
影响因子：
4.2
作者：
Yanai, Douglas;Weiland, James D.;Humayun, Mark S.
通讯作者：
Humayun, Mark S.