Cell-based therapies for diabetic complications.

Cell-based therapies for diabetic complications.
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DOI:
10.1155/2012/872504
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发表时间:
2012
影响因子:
--
通讯作者:
Secchiero P
Secchiero P
中科院分区:
其他
文献类型:
--
作者:
Bernardi S;Severini GM;Zauli G;Secchiero P

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近年来,越来越多的实验证据支持这样的观点,即糖尿病患者可能会从基于细胞的治疗中受益匪浅,其中包括使用成人干细胞和/或祖细胞。特别是,间充质干细胞和内皮祖细胞循环池是迄今为止被建议用于治疗糖尿病患者血管并发症的研究最多的细胞群。我们回顾了支持在这种情况下使用它们的证据,这些细胞到目前为止已经显示出的治疗益处,以及基于细胞的治疗在糖尿病并发症中提出的挑战。
In recent years, accumulating experimental evidence supports the notion that diabetic patients may greatly benefit from cell-based therapies, which include the use of adult stem and/or progenitor cells. In particular, mesenchymal stem cells and the circulating pool of endothelial progenitor cells have so far been the most studied populations of cells proposed for the treatment of vascular complications affecting diabetic patients. We review the evidence supporting their use in this setting, the therapeutic benefits that these cells have shown so far as well as the challenges that cell-based therapies in diabetic complications put out.
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