Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases.
Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases.
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DOI：
10.1146/annurev-genet-120417-031534
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发表时间：
2018-11-23
影响因子：
11.1
通讯作者：
Gage FH
中科院分区：
文献类型：
--
作者：
Mertens J;Reid D;Lau S;Kim Y;Gage FH
与年龄相关的神经系统疾病对生物医学研究来说是一个巨大的挑战，因为我们仍在努力了解衰老过程与疾病表现之间的联系。老年人的各种病症并非直接由基因突变、毒素或传染源引起，而是主要由生物衰老的多种表现引起。因此，生成适当的模型系统来研究人类神经系统的衰老需要超越转基因和药物诱导模型的新概念。尽管获得活的人脑标本的机会有限，并且诱导多能干细胞模型由于与重编程相关的细胞复兴而面临限制，但将体细胞直接转化为诱导神经元可以产生捕获衰老许多方面的人类神经元。在这里，我们回顾了利用人类细胞重编程模型探索与年龄相关的神经退行性疾病的进展，并讨论了该领域的一般概念、前景和局限性。
Age-associated neurological diseases represent a profound challenge in biomedical research as we are still struggling to understand the interface between the aging process and the manifestation of disease. Various pathologies in the elderly do not directly result from genetic mutations, toxins, or infectious agents but are primarily driven by the many manifestations of biological aging. Therefore, the generation of appropriate model systems to study human aging in the nervous system demands new concepts that lie beyond transgenic and drug-induced models. Although access to viable human brain specimens is limited and induced pluripotent stem cell models face limitations due to reprogramming-associated cellular rejuvenation, the direct conversion of somatic cells into induced neurons allows for the generation of human neurons that capture many aspects of aging. Here, we review advances in exploring age-associated neurodegenerative diseases using human cell reprogramming models, and we discuss general concepts, promises, and limitations of the field.
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影响因子：
15.1
作者：
Duan L;Bhattacharyya BJ;Belmadani A;Pan L;Miller RJ;Kessler JA
通讯作者：
Kessler JA
DNA甲基化模式和转录连通性降低定义了人皮肤老化。
影响因子：
7.8
作者：
Bormann F;Rodríguez-Paredes M;Hagemann S;Manchanda H;Kristof B;Gutekunst J;Raddatz G;Haas R;Terstegen L;Wenck H;Kaderali L;Winnefeld M;Lyko F
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Lyko F
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64.5
作者：
Enge M;Arda HE;Mignardi M;Beausang J;Bottino R;Kim SK;Quake SR
通讯作者：
Quake SR
影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
影响因子：
3.7
作者：
Bozdag S;Li A;Riddick G;Kotliarov Y;Baysan M;Iwamoto FM;Cam MC;Kotliarova S;Fine HA
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Fine HA