The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles.
The Therapeutic Potential of the Anticancer Activity of Fucoidan: Current Advances and Hurdles.
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岩藻依聚糖抗癌活性的治疗潜力：当前进展和障碍
DOI：
10.3390/md19050265
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发表时间：
2021-05-10
期刊：
影响因子：
5.4
通讯作者：
Yadav D
中科院分区：
文献类型：
--
作者：
Jin JO;Chauhan PS;Arukha AP;Chavda V;Dubey A;Yadav D
几种类型的癌症共享细胞和分子行为。虽然许多化疗药物被设计成削弱癌细胞的防御，但这些药物也可能对健康组织产生细胞毒性作用。岩藻依聚糖硫酸酯是一种来源于褐藻的硫酸化岩藻糖基多糖，由于其对多种癌症类型的抗癌作用而作为抗肿瘤药物受到广泛关注。岩藻依聚糖的抗癌机制包括细胞周期阻滞、细胞凋亡诱发和细胞毒性自然杀伤细胞和巨噬细胞的刺激。岩藻依聚糖硫酸酯还可防止与化疗药物和辐射诱导的损伤相关的毒性。褐藻糖胶与现有抗癌药物的协同作用促使研究人员探索其治疗潜力。本文综述了褐藻糖胶减缓肿瘤生长、杀死癌细胞以及与癌症化疗药物相互作用的机制。本文还讨论了岩藻依聚糖作为抗癌剂的发展障碍。
Several types of cancers share cellular and molecular behaviors. Although many chemotherapy drugs have been designed to weaken the defenses of cancer cells, these drugs may also have cytotoxic effects on healthy tissues. Fucoidan, a sulfated fucose-based polysaccharide from brown algae, has gained much attention as an antitumor drug owing to its anticancer effects against multiple cancer types. Among the anticancer mechanisms of fucoidan are cell cycle arrest, apoptosis evocation, and stimulation of cytotoxic natural killer cells and macrophages. Fucoidan also protects against toxicity associated with chemotherapeutic drugs and radiation-induced damage. The synergistic effect of fucoidan with existing anticancer drugs has prompted researchers to explore its therapeutic potential. This review compiles the mechanisms through which fucoidan slows tumor growth, kills cancer cells, and interacts with cancer chemotherapy drugs. The obstacles involved in developing fucoidan as an anticancer agent are also discussed in this review.
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影响因子：
5.4
作者：
Chen MC;Hsu WL;Hwang PA;Chou TC
通讯作者：
Chou TC
从甲壳虫冈村甲壳虫中提取的口服岩藻糖素对肿瘤含量小鼠模型中肿瘤生长和存活时间的影响。
影响因子：
5.4
作者：
Azuma K;Ishihara T;Nakamoto H;Amaha T;Osaki T;Tsuka T;Imagawa T;Minami S;Takashima O;Ifuku S;Morimoto M;Saimoto H;Kawamoto H;Okamoto Y
通讯作者：
Okamoto Y
影响因子：
2.9
作者：
Burney M;Mathew L;Gaikwad A;Nugent EK;Gonzalez AO;Smith JA
通讯作者：
Smith JA
影响因子：
2.8
作者：
Abudabbus, Aisha;Badmus, Jelili A.;Hiss, Donavon
通讯作者：
Hiss, Donavon
影响因子：
5.6
作者：
Atashrazm, Farzaneh;Lowenthal, Ray M.;Dickinson, Joanne L.
通讯作者：
Dickinson, Joanne L.