Effects of oral administration of fucoidan extracted from Cladosiphon okamuranus on tumor growth and survival time in a tumor-bearing mouse model.
Effects of oral administration of fucoidan extracted from Cladosiphon okamuranus on tumor growth and survival time in a tumor-bearing mouse model.
复制标题
从甲壳虫冈村甲壳虫中提取的口服岩藻糖素对肿瘤含量小鼠模型中肿瘤生长和存活时间的影响。
DOI：
10.3390/md10102337
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发表时间：
2012-10
期刊：
影响因子：
5.4
通讯作者：
Okamoto Y
中科院分区：
文献类型：
--
作者：
Azuma K;Ishihara T;Nakamoto H;Amaha T;Osaki T;Tsuka T;Imagawa T;Minami S;Takashima O;Ifuku S;Morimoto M;Saimoto H;Kawamoto H;Okamoto Y
我们用荷瘤小鼠模型评价了从冈村枝管吸虫中提取的岩藻糖胶的口服抗肿瘤活性。所用材料包括低分子岩藻糖胶(LMWF：6.5-40 kDa)、中分子岩藻糖胶(IMWF：110-138 kDa)和高分子量岩藻糖胶(HMWF：300-330 kDa)。IMWF组肿瘤生长受到明显抑制。与对照组(饲喂无褐藻糖胶的小鼠)相比，LMWF组和HMWF组小鼠的存活时间显著延长。对照组、LMWF组、IMWF组和HMWF组的中位生存期分别为23、46、40和43天。研究还发现，口服岩藻糖胶增加了脾中自然杀伤细胞的数量。此外，从myd-88基因敲除小鼠的实验结果中发现，这些效应与肠道免疫有关。这些结果表明岩藻糖胶是一种候选的抗肿瘤功能食品。
We evaluated the anti-tumor activities of the oral administration of fucoidan extracted from Cladosiphon okamuranus using a tumor (colon 26)-bearing mouse model. The materials used included low-molecular-weight fucoidan (LMWF: 6.5–40 kDa), intermediate-molecular-weight fucoidan (IMWF: 110–138 kDa) and high-molecular-weight fucoidan (HMWF: 300–330 kDa). The IMWF group showed significantly suppressed tumor growth. The LMWF and HMWF groups showed significantly increased survival times compared with that observed in the control group (mice fed a fucoidan-free diet). The median survival times in the control, LMWF, IMWF and HMWF groups were 23, 46, 40 and 43 days, respectively. It was also found that oral administration of fucoidan increased the population of natural killer cells in the spleen. Furthermore, from the results of the experiment using Myd-88 knockout mice, it was found that these effects are related to gut immunity. These results suggest that fucoidan is a candidate anti-tumor functional food.
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影响因子：
2.7
作者：
Maruyama, Hiroko;Tamauchi, Hidekazu;Nakano, Takahisa
通讯作者：
Nakano, Takahisa
影响因子：
3.1
作者：
Bilan, MI;Grachev, AA;Usov, AI
通讯作者：
Usov, AI
DOI：
10.3390/molecules13081671
发表时间：
2008-08-12
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Li B;Lu F;Wei X;Zhao R
通讯作者：
Zhao R
影响因子：
3.7
作者：
Croci DO;Cumashi A;Ushakova NA;Preobrazhenskaya ME;Piccoli A;Totani L;Ustyuzhanina NE;Bilan MI;Usov AI;Grachev AA;Morozevich GE;Berman AE;Sanderson CJ;Kelly M;Di Gregorio P;Rossi C;Tinari N;Iacobelli S;Rabinovich GA;Nifantiev NE;Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO), Italy
通讯作者：
Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO), Italy
影响因子：
4.4
作者：
SALYERS, AA;VERCELLOTTI, JR;WILKINS, TD
通讯作者：
WILKINS, TD