Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance.
Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance.
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DOI：
10.1016/j.numecd.2010.09.003
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Ordovás JM
中科院分区：
文献类型：
--
作者：
Smith CE;Arnett DK;Corella D;Tsai MY;Lai CQ;Parnell LD;Lee YC;Ordovás JM
大量营养素摄入和遗传变异已被证明相互作用，以改变胰岛素抵抗的风险，但复制基因营养相互作用在独立的人群可能难以实现。饱和脂肪和碳水化合物先前显示与围脂蛋白（PLIN）变体的胰岛素抵抗基因型相互作用，PLIN是主要的脂肪细胞相关蛋白和脂肪细胞代谢的调节剂。我们研究了PLIN 11482 G>A（rs 894160）对美国男性（n=462）和女性（n=508）（平均值±SD，49±16岁）中胰岛素抗性的相同相互作用。在多变量线性回归模型中，我们发现女性中作为连续变量的饱和脂肪与碳水化合物摄入的比率与用于HOMA-IR（胰岛素抵抗的稳态模型评估）的PLIN 11482 G>A之间的显著（P<0.05）相互作用。对于次要等位基因携带者，而非携带者，随着饱和脂肪与碳水化合物摄入比例的增加，预测的HOMA-IR显著增加（P=0.002）。通过将饱和脂肪与碳水化合物的摄入比例分为高、低两类，我们发现胰岛素和HOMA-IR之间存在显著的交互作用（P<0.05）。当饱和脂肪与碳水化合物的比例高时，胰岛素和HOMA-IR在次要等位基因携带者中较高（分别为P=0.004和P=0.003），但当比例低时没有差异。当饱和脂肪和碳水化合物被分为高和低作为个体宏量营养素时，观察到类似的模式或趋势。先前报道的大量营养素摄入与胰岛素抵抗的PLIN基因型之间的相互作用的复制加强了在胰岛素抵抗的饮食管理中应用基因型信息的潜在有用性。
Macronutrient intakes and genetic variants have been shown to interact to alter the risk of insulin resistance, but replication of gene-nutrient interactions across independent populations may be difficult to achieve. Saturated fat and carbohydrate were previously shown to interact with genotype for insulin resistance for a variant of perilipin (PLIN), the major adipocyte-associated protein and a regulator of adipocyte metabolism. We investigated the same interaction for PLIN 11482G>A (rs894160) on insulin resistance in US men(n=462) and women(n=508) (mean ±SD, 49±16 years). In multivariate linear regression models, we found a significant (P<0.05) interaction between the ratio of saturated fat to carbohydrate intake as a continuous variable and PLIN 11482G>A for HOMA-IR (homeostasis model assessment of insulin resistance) in women. For carriers of the minor allele but not for non-carriers, as the ratio of saturated fat to carbohydrate intake increased, predicted HOMA-IR increased significantly (P=0.002). By dichotomizing the ratio of saturated fat to carbohydrate intake into high and low, we found significant interaction terms for insulin and HOMA-IR (P<0.05). When the ratio of saturated fat to carbohydrate was high, insulin and HOMA-IR were higher in minor allele carriers (P=0.004 and P=0.003, respectively), but did not differ when the ratio was low. Similar patterns or trends were observed when saturated fat and carbohydrate were dichotomized into high and low as individual macronutrients. Replication of the previously reported interaction between macronutrient intakes and PLIN genotype for insulin resistance reinforces the potential usefulness of applying genotype information in the dietary management of insulin resistance.
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影响因子：
16.2
作者：
Corella, Dolores;Qi, Lu;Ordovas, Jose M.
通讯作者：
Ordovas, Jose M.
影响因子：
4.8
作者：
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通讯作者：
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影响因子：
9.8
作者：
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通讯作者：
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影响因子：
3.5
作者：
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通讯作者：
Ordovas, JM
DOI：
10.1016/j.numecd.2007.09.003
发表时间：
2009-06-01
影响因子：
3.9
作者：
Culling, K. S.;Neil, H. A. W.;Frayn, K. N.
通讯作者：
Frayn, K. N.