Refined chromosome study helps define prognostic subgroups in most patients with primary myelodysplastic syndrome and acute myelogenous leukaemia

Refined chromosome study helps define prognostic subgroups in most patients with primary myelodysplastic syndrome and acute myelogenous leukaemia
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精细染色体研究有助于确定大多数原发性骨髓增生异常综合征和急性髓性白血病患者的预后亚组

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发表时间:
1988
影响因子:
6.5
通讯作者:
R. Brunning
R. Brunning
中科院分区:
医学2区
文献类型:
--
作者:
J. Yunis;M. Lobell;M. Arnesen;M. Oken;M. Mayer;R. Rydell;R. Brunning

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基于对284例原发性骨髓增生异常综合征(MDS)和急性髓性白血病(AML)的连续成人患者进行的6年半研究,我们发现精细染色体分析可用作绝大多数MDS和AML患者的独立预后指标。在MDS中,FAB亚型也被发现具有预后价值,当考虑到染色体发现时,这一点得到了加强。在AML中,患者的年龄与大多数患者的预后预测中的染色体变化比FAB分类更密切相关。
Based on a 6·1/2‐year study of 284 consecutive adult patients with primary myelodysplastic syndrome (MDS) and and acute myelogenous leukaemia (AML), we have found that refined chromosome analysis can be used as an independent prognostic indicator in the great majority of patients with MDS and AML. In MDS, the FAB subtype was also found to have prognostic value and this was enhanced when the chromosomal findings were taken into consideration. In AML, the age of the patient correlated more closely with the chromosomal changes in predicting prognosis in most patients than did the FAB classification.
高分辨率染色体作为成人急性非淋巴细胞白血病的独立预后指标。
DOI: 10.1056/nejm198409273111302
发表时间: 1984
期刊: The New England journal of medicine
影响因子: --
作者:
Yunis,JJ;Brunning,RD;Howe,RB;Lobell,M
通讯作者: Lobell,M
DOI: --
发表时间: 1984
影响因子: --
作者:
通讯作者: --
DOI: 10.1126/science.7079737
发表时间: 1982-01-01
期刊: SCIENCE
影响因子: 56.9
作者:
ROWLEY, JD
通讯作者: ROWLEY, JD