The impact of heterogeneous transmission on the establishment and spread of antimalarial drug resistance.
The impact of heterogeneous transmission on the establishment and spread of antimalarial drug resistance.
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DOI：
10.1016/j.jtbi.2013.09.022
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发表时间：
2014-01-07
影响因子：
2
通讯作者：
Klein, Eili Y.
中科院分区：
文献类型：
--
作者：
Klein, Eili Y.
尽管通过扩展疟疾的经典模型获得了重要的见解，但由于对宿主内部竞争的多个简单的疟疾感染建模的复杂性，尚未完全探索其他因素，例如免疫学，异质咬合和药物使用差异这些因素对于理解如何控制抗药性的青蒿素的传播至关重要，阿梅米辛在东南亚出现。在人口水平上发挥作用，但是个人在传播事件中竞争的结果。为了嵌入主机竞争中，我们使用了一个基于代理的框架，该框架是为了了解Ross-Macdonald类型模型的经典假设如何已经很好地描述和分析了疾病的动力学，而结构是对经典的Ross-Macdonald类型模型的随机类似物，但该模型仍然基于个体，因此可以探索内部竞争的各个方面。我们使用此框架来探索异质咬合和传播在人群中的建立和传播中的作用。人口，但是一旦建立了电阻，它会加快这些结果的差异，这是由于咬合的偏斜分布，这使得向前传播的可能性很低，并建议针对提供疫苗的“核心”群体大多数位可能会大大减慢电阻的传播。
Despite the important insights gained by extending the classical models of malaria, other factors, such as immunity, heterogeneous biting, and differential patterns of drug use have not been fully explored due to the complexity of modeling multiple simultaneous malaria infections competing within a host. Understanding these factors is important for understanding how to control the spread of drug resistance to artemisinin which is just emerging in Southeast Asia. The emergence of resistance plays out at the population level, but is the result of competition within individuals for transmission events. Most studies of drug resistance evolution have focused on transmission between hosts and ignored the role of within-host competition due to the inherent complexity of modeling at multiple scales. To embed within-host competition in the model, we used an agent-based framework that was developed to understand how deviations from the classical assumptions of the Ross-MacDonald type models, which have been well-described and analyzed, impact the dynamics of disease. While structured to be a stochastic analogue to classical Ross-Macdonald type models, the model is nonetheless based on individuals, and thus aspects of within-host competition can be explored. We use this framework to explore the role of heterogeneous biting and transmission on the establishment and spread of resistance in a population. We find that heterogeneous transmission slows the establishment of resistance in a population, but once resistance is established, it speeds the spread of resistance through the population. These results are due to the skewed distribution of biting which makes onward transmission a low probability and suggests that targeting the “core” group of individuals that provide the vast majority of bites could significantly slow the spread of resistance.
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影响因子：
3.7
作者：
Jiang H;Patel JJ;Yi M;Mu J;Ding J;Stephens R;Cooper RA;Ferdig MT;Su XZ
通讯作者：
Su XZ
临床免疫宿主是对药物敏感疟疾寄生虫的避难所。
影响因子：
3
作者：
Klein EY;Smith DL;Boni MF;Laxminarayan R
通讯作者：
Laxminarayan R
DOI：
10.1016/0035-9203(95)90406-9
发表时间：
1995-11-01
影响因子：
2.2
作者：
Knols, BGJ;deJong, R;Takken, W
通讯作者：
Takken, W
影响因子：
2.4
作者：
Hastings, I. M.
通讯作者：
Hastings, I. M.
DOI：
10.1098/rspb.2012.1064
发表时间：
2012-09-22
影响因子：
4.7
作者：
Klein, Eili Y.;Smith, David L.;Levin, Simon
通讯作者：
Levin, Simon