The area of residual tumor predicts esophageal squamous cell carcinoma prognosis following neoadjuvant chemotherapy
The area of residual tumor predicts esophageal squamous cell carcinoma prognosis following neoadjuvant chemotherapy
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残留肿瘤面积预测食管鳞癌新辅助化疗后的预后
DOI：
10.1007/s00432-022-04366-7
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发表时间：
2022
影响因子：
3.6
通讯作者：
Sakashita Shingo
中科院分区：
文献类型：
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作者：
Adachi Masahiro;Aoyama Naoki;Kojima Motohiro;Sakamoto Naoya;Miyazaki Saori;Taki Tetsuro;Watanabe Reiko;Matsuura Kazuto;Kotani Daisuke;Kojima Takashi;Fujita Takeo;Tabuchi Keiji;Ishii Genichiro;Sakashita Shingo
目的探讨残存肿瘤面积在食管鳞癌新辅助化疗中的应用价值。方法收集186例食管鳞癌新辅助化疗后手术切除患者。使用数字图像测量标本最大平面上的残留肿瘤面积，并将患者分为三组：0( = 区0mm2)、低( = 区0-40mm2)和高( ≥ 区40mm2)。结果肿瘤残留面积中位数为15.0mm2(0~1,448.8mm2)。与0和Low组相比，HIGH组无复发生存率(All P<； .001)和总生存率(P<； .001[vs.0]和P= .017[VS Low])显著降低。残留肿瘤面积、PYN、肿瘤消退分级和淋巴血管侵犯是无复发生存的独立预测因素。按残存肿瘤面积和淋巴血管侵犯面积进行分组，高和/或淋巴血管侵犯( +)组的无复发生存率明显低于0组和低/淋巴管侵犯( −)组。但0组与低/淋巴血管侵袭( −)组的无复发生存率差异无统计学意义。结论残存肿瘤面积是食管鳞癌新辅助化疗的一个有前景的组织病理学预后因素。此外，它可能是术后化疗选择的候选组织病理学因素。
PurposeTo clarify the utility of the area of residual tumor for patients with esophageal squamous cell cancer treated with neoadjuvant chemotherapy.MethodsWe enrolled 186 patients with esophageal squamous cell cancer who underwent surgical resection following neoadjuvant chemotherapy at our hospital. Using digital images, we measured the area of residual tumor at the maximum plane of the specimen and divided the patient into three groups as follows: 0 (area = 0 mm2), low (area = 0–40 mm2), and high (area ≥ 40 mm2). The clinicopathological factors and prognosis were compared among these groups.ResultsThe median area of the residual tumor was 15.0 mm2 (range 0–1,448.8 mm2). Compared with the 0 and low group, the high group was significantly associated with poorer recurrence-free survival (allP< .001) and overall survival (P< .001 [vs. 0] andP= .017 [vs low]). The area of residual tumor, ypN, tumor regression grade, and lymphovascular invasion were independent predictors of recurrence-free survival. By dividing the patients using a combination of the area of residual tumor and lymphovascular invasion, the high and/or lymphovascular invasion ( +) group displayed significantly poor recurrence-free survival than the 0 group and low/lymphovascular invasion ( −) group. However, there was no significant difference in the recurrence-free survival between the 0 group and low/lymphovascular invasion ( −) group.ConclusionThe area of residual tumor is a promising histopathological prognostic factor for patients with esophageal squamous cell cancer treated with neoadjuvant chemotherapy. Moreover, it is a possible candidate histopathological factor for postoperative chemotherapy selection.
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DOI：
10.1111/dote.12538
发表时间：
2016-11
期刊：
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
影响因子：
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作者：
Rice TW;Ishwaran H;Kelsen DP;Hofstetter WL;Apperson-Hansen C;Blackstone EH;Worldwide Esophageal Cancer Collaboration Investigators
通讯作者：
Worldwide Esophageal Cancer Collaboration Investigators
残留癌体积可预测食管鳞状细胞癌新辅助化疗后的临床结果
影响因子：
1.2
作者：
Ryuta Nakao;E. Konishi;H. Fujiwara;E. Otsuji;I. Yokota;Y. Urata;A. Yanagisawa
通讯作者：
A. Yanagisawa
日本食管癌的分类，第11版：第一部分。
DOI：
10.1007/s10388-016-0551-7
发表时间：
2017
期刊：
Esophagus : official journal of the Japan Esophageal Society
影响因子：
--
作者：
Japan Esophageal Society
通讯作者：
Japan Esophageal Society
胰腺导管腺癌新辅助治疗切除后肿瘤消退的更客观评估：多个肿瘤消退分级系统比较的多中心研究
DOI：
--
发表时间：
2019
期刊：
影响因子：
--
作者：
Matsuda Y;Ohkubo S;Fukumura Y;Hirabayashi K;Yamaguchi H;Sahara Y;Kawanishi A;Takahashi S;Arai T;Kojima M;Mino-Kenudson M
通讯作者：
Mino-Kenudson M
残余肿瘤面积是接受术前治疗的直肠癌患者的一个强有力的预后标志物
影响因子：
5.7
作者：
N. Sakuyama;M. Kojima;Shingo Kawano;Y. Matsuda;M. Mino‐Kenudson;A. Ochiai;Masaaki Ito
通讯作者：
Masaaki Ito