Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge.
Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge.
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DOI：
10.1016/j.eclinm.2020.100683
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发表时间：
2021-01
影响因子：
15.1
通讯作者：
Neubauer S
中科院分区：
文献类型：
--
作者：
Raman B;Cassar MP;Tunnicliffe EM;Filippini N;Griffanti L;Alfaro-Almagro F;Okell T;Sheerin F;Xie C;Mahmod M;Mózes FE;Lewandowski AJ;Ohuma EO;Holdsworth D;Lamlum H;Woodman MJ;Krasopoulos C;Mills R;McConnell FAK;Wang C;Arthofer C;Lange FJ;Andersson J;Jenkinson M;Antoniades C;Channon KM;Shanmuganathan M;Ferreira VM;Piechnik SK;Klenerman P;Brightling C;Talbot NP;Petousi N;Rahman NM;Ho LP;Saunders K;Geddes JR;Harrison PJ;Pattinson K;Rowland MJ;Angus BJ;Gleeson F;Pavlides M;Koychev I;Miller KL;Mackay C;Jezzard P;Smith SM;Neubauer S
人们对冠状病毒病 (COVID-19) 对器官健康、运动能力、认知、生活质量和心理健康的中期影响知之甚少。 58 名出院后的 COVID-19 患者和 30 名年龄、性别、体重指数合并症匹配的对照者入组进行多器官（脑、肺、心脏、肝脏和肾脏）磁共振成像 (MRI)、肺活量测定、六分钟步行测试、心肺运动测试 (CPET)、生活质量、认知和心理健康评估。发病 2-3 个月后，64% 的患者出现呼吸困难，55% 的患者报告疲劳。 MRI 发现肺部（60%）、心脏（26%）、肝脏（10%）和肾脏（29%）出现异常。患者在脑部 MRI 上表现出丘脑、丘脑后辐射和矢状层的变化，并表现出认知能力受损，特别是在执行和视觉空间领域。运动耐力（最大耗氧量和 CPET 通气效率）和六分钟步行距离显着降低。肺外 MRI 异常的程度和运动不耐受的程度与炎症和急性疾病严重程度的血清标志物相关。与对照组相比，患者自我报告的抑郁症状负担更高，并且在生活质量的各个方面都经历了显着损害（p<0.0001 至 0.044）。很大一部分出院患者出现呼吸困难、疲劳、抑郁和运动能力有限的症状。持续的肺部和肺外器官 MRI 检查结果在患者中很常见，并且与炎症和急性疾病的严重程度有关。 NIHR 牛津和牛津健康生物医学研究中心、英国心脏基金会卓越研究中心、UKRI、Wellcome Trust、英国心脏基金会。
The medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality of life and mental health are poorly understood. Fifty-eight COVID-19 patients post-hospital discharge and 30 age, sex, body mass index comorbidity-matched controls were enrolled for multiorgan (brain, lungs, heart, liver and kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary exercise test (CPET), quality of life, cognitive and mental health assessments. At 2–3 months from disease-onset, 64% of patients experienced breathlessness and 55% reported fatigue. On MRI, abnormalities were seen in lungs (60%), heart (26%), liver (10%) and kidneys (29%). Patients exhibited changes in the thalamus, posterior thalamic radiations and sagittal stratum on brain MRI and demonstrated impaired cognitive performance, specifically in the executive and visuospatial domains. Exercise tolerance (maximal oxygen consumption and ventilatory efficiency on CPET) and six-minute walk distance were significantly reduced. The extent of extra-pulmonary MRI abnormalities and exercise intolerance correlated with serum markers of inflammation and acute illness severity. Patients had a higher burden of self-reported symptoms of depression and experienced significant impairment in all domains of quality of life compared to controls (p<0.0001 to 0.044). A significant proportion of patients discharged from hospital reported symptoms of breathlessness, fatigue, depression and had limited exercise capacity. Persistent lung and extra-pulmonary organ MRI findings are common in patients and linked to inflammation and severity of acute illness. NIHR Oxford and Oxford Health Biomedical Research Centres, British Heart Foundation Centre for Research Excellence, UKRI, Wellcome Trust, British Heart Foundation.
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影响因子：
10
作者：
Hui, DS;Joynt, GM;Sung, JJY
通讯作者：
Sung, JJY
影响因子：
3.3
作者：
Haddad, F;Zaldivar, F;Adams, GR
通讯作者：
Adams, GR
影响因子：
--
作者：
Brickman, Adam M.;Provenzano, Frank A.;Muraskin, Jordan;Manly, Jennifer J.;Blum, Sonja;Apa, Zoltan;Stern, Yaakov;Brown, Truman R.;Luchsinger, Jose A.;Mayeux, Richard
通讯作者：
Mayeux, Richard
影响因子：
9.9
作者：
Miwa, Kaori;Tanaka, Makiko;Kitagawa, Kazuo
通讯作者：
Kitagawa, Kazuo
DOI：
10.3174/ajnr.a1461
发表时间：
2009-02
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Mittal S;Wu Z;Neelavalli J;Haacke EM
通讯作者：
Haacke EM