Regional white matter hyperintensity volume, not hippocampal atrophy, predicts incident Alzheimer disease in the community.
Regional white matter hyperintensity volume, not hippocampal atrophy, predicts incident Alzheimer disease in the community.
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DOI：
10.1001/archneurol.2012.1527
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发表时间：
2012-12
影响因子：
--
通讯作者：
Mayeux, Richard
中科院分区：
文献类型：
--
作者：
Brickman, Adam M.;Provenzano, Frank A.;Muraskin, Jordan;Manly, Jennifer J.;Blum, Sonja;Apa, Zoltan;Stern, Yaakov;Brown, Truman R.;Luchsinger, Jose A.;Mayeux, Richard
新发阿尔茨海默病（AD）通常归因于海马体的退行性变化。然而，区域分布的小血管脑血管疾病（在 MRI 上表现为白质高信号 (WMH)）的贡献仍不清楚。在流行病学研究中确定区域 WMH 和海马体积是否可以预测 AD 事件。对曼哈顿北部老年人进行的基于社区的纵向流行病学研究。华盛顿高地/因伍德哥伦比亚老龄化项目 2005 年至 2007 年间，717 名非痴呆参与者接受了 MRI 扫描。平均 40.28 (SD=9.77) 个月后，503 人返回进行后续临床检查，其中 46 人符合痴呆症标准（45 人患有 AD）。得出区域 WMH 和相对海马体积。运行三个 Cox 比例风险模型来预测痴呆症，并控制相关变量。第一个包括所有 WMH 测量值；第二个包括相对海马体积；第三个结合了两个测量结果。阿尔茨海默病事件。顶叶白质高信号体积可预测痴呆发生时间（HR=1.194，p=0.031）。当单独考虑时（HR=0.419，p=0.768）或与模型中包含的 WMH 测量值一起考虑（HR=0.302，p=0.701），相对海马体积并不能预测痴呆的发生。将海马体积纳入模型中并没有显着改变顶叶 WMH 的预测效用（HR=1.197，p=0.049）。研究结果强调了 WMH 与 AD 关联的区域特异性。目前尚不清楚顶叶 WMH 是否仅代表脑血管负担的标志物或与其他区域相比表明明显的损伤。未来的工作应阐明 WMH 和 AD 病理学之间的致病机制。
New onset Alzheimer’s disease (AD) is often attributed to degenerative changes in the hippocampus. However, the contribution of regionally distributed small vessel cerebrovascular disease, visualized as white matter hyperintensities (WMH) on MRI, remains unclear. To determine whether regional WMH and hippocampal volume predict incident AD in an epidemiological study. A longitudinal community-based epidemiological study of older adults from northern Manhattan. The Washington Heights/Inwood Columbia Aging Project Between 2005 and 2007, 717 non-demented participants received MRI scans. An average of 40.28 (SD=9.77) months later, 503 returned for follow-up clinical examination and 46 met criteria for incident dementia (45 with AD). Regional WMH and relative hippocampal volumes were derived. Three Cox proportional hazards models were run to predict incident dementia, controlling for relevant variables. The first included all WMH measurements; the second included relative hippocampal volume; and the third combined the two measurements. Incident Alzheimer’s disease. White matter hyperintensity volume in the parietal lobe predicted time to incident dementia (HR=1.194, p=0.031). Relative hippocampal volume did not predict incident dementia when considered alone (HR=0.419, p=0.768) or with the WMH measures included in the model (HR=0.302, p=0.701). Including hippocampal volume in the model did not notably alter the predictive utility of parietal lobe WMH (HR=1.197, p=0.049). The findings highlight the regional specificity of the association of WMH with AD. It is not clear whether parietal WMH solely represent a marker for cerebrovascular burden or point to distinct injury compared to other regions. Future work should elucidate pathogenic mechanisms linking WMH and AD pathology.
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DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
4.2
作者：
Jacobs, Heidi I. L.;Visser, Pieter Jelle;Verhey, Frans R. J.
通讯作者：
Verhey, Frans R. J.
影响因子：
48
作者：
Barnes, Deborah E.;Yaffe, Kristine
通讯作者：
Yaffe, Kristine
影响因子：
11.3
作者：
Brickman AM;Sneed JR;Provenzano FA;Garcon E;Johnert L;Muraskin J;Yeung LK;Zimmerman ME;Roose SP
通讯作者：
Roose SP
影响因子：
--
作者：
Brickman, Adam M.;Honig, Lawrence S.;Scarmeas, Nikolaos;Tatarina, Oksana;Sanders, Linda;Albert, Marilyn S.;Brandt, Jason;Blacker, Deborah;Stern, Yaakov
通讯作者：
Stern, Yaakov