Central Neurocytoma: Clinical, Pathological, and Imaging Findings in 5 Cases
Central Neurocytoma: Clinical, Pathological, and Imaging Findings in 5 Cases
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中枢神经细胞瘤5例临床、病理及影像学表现
DOI：
10.1097/wnq.0b013e318205171b
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发表时间：
2011-02
影响因子：
--
通讯作者：
Guo, Ying
中科院分区：
文献类型：
--
作者：
Wang, Hui;Li, Wen-sheng;Shi, De-jin;He, Hai-yong;Liang, Chao-feng;Guo, Ying
背景为提高中枢神经细胞瘤（CNC）的治疗效果，我们对其临床、病理及影像学表现进行探讨。方法回顾性分析5例CNC的临床表现、病理特点、影像学表现及显微手术治疗效果。结果CNC多位于侧脑室前正中区、室间孔附近，并附着于侧脑室壁或透明隔。CT表现为等密度或稍高密度肿块，其内可见多发小的低密度坏死灶，未见钙化; MRI表现为T1 WI等或稍低信号，T2 WI不均匀稍高信号，增强后轻度或中度强化。免疫组化显示所有病例神经元特异性烯醇化酶均呈阳性，突触素4例阳性，1例可能阳性，胶质纤维酸性蛋白4例阴性，1例阳性。5例均行显微手术治疗。全切除3例，次全切除1例，部分切除1例。2例术后放疗，随访3个月~ 4年。结论CNC主要位于脑室前区或室间孔附近。影像学表现具有一定特征。通过显微手术切除CNC可以显着降低残疾和死亡率。术后放疗可减少CNC复发。
BackgroundTo enhance treatment effectiveness of central neurocytoma (CNC), we explore its clinical, pathological, and imaging findings. MethodsThe clinical manifestation, pathological features, imaging findings, and microsurgical treatment effectiveness were retrospectively analyzed in 5 cases of CNC. ResultsThe majority of CNC was located in the anterocentral region of the lateral ventricle and near the foramen of monro, and was attached to the wall of lateral ventricle or the septum pellucidum. Computed tomography showed that isodense or slight hyperdense mass in which there were multiple small hypodense necrotic lesions, but no calcification was found. Magnetic resonance indicated isointensity or slight hypointensity on T1WI, nonuniform slight hyperintensity on T2WI, and post-contrast slight or moderate enhancement. Immunohistochemistry suggested that neuron-specific enolase was positive in all the cases, synaptophysin was positive in 4 cases and probable positive in 1 case, glial fibrillary acidic protein was negative in 4 cases and positive in 1 case. All the 5 cases underwent microsurgery. Total removal was performed in 3 cases, subtotal removal in 1 case, and partial removal in 1 case. The last 2 cases received postoperative radiotherapy and all the cases were followed between 3 months and 4 years. ConclusionsCNC was mainly located in the anterior region of the brain ventricle or near the foramen of monro. Imaging findings exhibited certain characteristics. CNC removal by microsurgery may markedly decrease disability and mortality. Postoperative radiotherapy may reduce CNC recurrence.
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DOI：
10.1007/s00381-008-0655-z
发表时间：
2008-05
期刊：
Child's Nervous System
影响因子：
--
作者：
M. Keřkovský;Karel Zitterbart;Karel Svoboda;J. Hřivňacká;Jarmila Skotáková;A. Šprláková‐Puková;M. Mechl
通讯作者：
M. Keřkovský;Karel Zitterbart;Karel Svoboda;J. Hřivňacká;Jarmila Skotáková;A. Šprláková‐Puková;M. Mechl
影响因子：
1.9
作者：
Chen, Chun-Lin;Shen, Chiung-Chyi;Lee, Hsu-Tung
通讯作者：
Lee, Hsu-Tung
影响因子：
4.8
作者：
D'Angelo, Vincenzo A.;Galarza, Marcelo;Carosi, Illuminato
通讯作者：
Carosi, Illuminato
影响因子：
6.2
作者：
D. Rades;S. Schild
通讯作者：
D. Rades;S. Schild
DOI：
--
发表时间：
2004
期刊：
Journal of China Medical Imaging
影响因子：
--
作者：
L. Bo
通讯作者：
L. Bo