Epigenetic control of the genome-lessons from genomic imprinting.
Epigenetic control of the genome-lessons from genomic imprinting.
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DOI：
10.3390/genes5030635
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发表时间：
2014-08-14
期刊：
影响因子：
3.5
通讯作者：
Ferguson-Smith AC
中科院分区：
文献类型：
--
作者：
Adalsteinsson BT;Ferguson-Smith AC
表观遗传机制通过写入、阅读和擦除染色质结构特征来调节基因组功能。这些对基因表达有影响，有助于正常和异常情况下细胞特性的建立、维持和动态变化。最近，大量的努力被用来对表观遗传标记的全基因组模式进行编目，从而建立参考表观基因组，这将加深我们对表观遗传标记对基因组调控和功能的贡献的理解，并有望进一步揭示疾病的病因。这些全球研究的基础是通过研究模型系统中的表观遗传机制而产生的较小规模的实验观察和问题。一个这样的系统是基因组印记，一个过程，导致单等位基因表达的基因在父母的起源特定的方式控制的一个层次的表观遗传事件，教会了我们很多关于动态之间的相互作用的关键监管机构的表观遗传控制。在这里，我们总结了一些最值得注意的教训，研究印迹揭示了表观遗传控制在更大范围内。具体来说，我们将考虑这些研究揭示了：DNA甲基化和转录控制之间的各种关系; DNA甲基化对重要蛋白质-DNA相互作用的调节; DNA甲基化和组蛋白修饰之间的相互作用;以及长非编码RNA的调节和功能。
Epigenetic mechanisms modulate genome function by writing, reading and erasing chromatin structural features. These have an impact on gene expression, contributing to the establishment, maintenance and dynamic changes in cellular properties in normal and abnormal situations. Great effort has recently been undertaken to catalogue the genome-wide patterns of epigenetic marks—creating reference epigenomes—which will deepen our understanding of their contributions to genome regulation and function with the promise of revealing further insights into disease etiology. The foundation for these global studies is the smaller scale experimentally-derived observations and questions that have arisen through the study of epigenetic mechanisms in model systems. One such system is genomic imprinting, a process causing the mono-allelic expression of genes in a parental-origin specific manner controlled by a hierarchy of epigenetic events that have taught us much about the dynamic interplay between key regulators of epigenetic control. Here, we summarize some of the most noteworthy lessons that studies on imprinting have revealed about epigenetic control on a wider scale. Specifically, we will consider what these studies have revealed about: the variety of relationships between DNA methylation and transcriptional control; the regulation of important protein-DNA interactions by DNA methylation; the interplay between DNA methylation and histone modifications; and the regulation and functions of long non-coding RNAs.
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影响因子：
46.9
作者：
Ball, Madeleine P.;Li, Jin Billy;Gao, Yuan;Lee, Je-Hyuk;LeProust, Emily M.;Park, In-Hyun;Xie, Bin;Daley, George Q.;Church, George M.
通讯作者：
Church, George M.
影响因子：
64.8
作者：
Ernst, Jason;Kheradpour, Pouya;Mikkelsen, Tarjei S.;Shoresh, Noam;Ward, Lucas D.;Epstein, Charles B.;Zhang, Xiaolan;Wang, Li;Issner, Robbyn;Coyne, Michael;Ku, Manching;Durham, Timothy;Kellis, Manolis;Bernstein, Bradley E.
通讯作者：
Bernstein, Bradley E.
影响因子：
46.9
作者：
Deng, Jie;Shoemaker, Robert;Xie, Bin;Gore, Athurva;LeProust, Emily M.;Antosiewicz-Bourget, Jessica;Egli, Dieter;Maherali, Nimet;Park, In-Hyun;Yu, Junying;Daley, George Q.;Eggan, Kevin;Hochedlinger, Konrad;Thomson, James;Wang, Wei;Gao, Yuan;Zhang, Kun
通讯作者：
Zhang, Kun
影响因子：
64.8
作者：
FERGUSONSMITH, AC;SASAKI, H;SURANI, MA
通讯作者：
SURANI, MA
影响因子：
16
作者：
Freitag, M;Hickey, PC;Selker, EU
通讯作者：
Selker, EU