Translation Animal Models of Diabetic Kidney Disease: Biochemical and Histological Phenotypes, Advantages and Limitations.
Translation Animal Models of Diabetic Kidney Disease: Biochemical and Histological Phenotypes, Advantages and Limitations.
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DOI：
10.2147/dmso.s408170
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发表时间：
2023
期刊：
影响因子：
--
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中科院分区：
文献类型：
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动物模型在研究疾病发病机制、开发新药、识别疾病危险标志物、改进防治手段等方面发挥着至关重要的作用。然而，糖尿病肾病（DKD）的建模给科学家们带来了挑战。虽然已经成功开发了许多模型，但没有一个模型能够涵盖人类DKD的所有关键特征。根据研究需要选择合适的模型是至关重要的，因为不同的模型会产生不同的表型，并且有其局限性。本文全面综述了DKD动物模型的生化和组织学表型、造模机制、优势和局限性，以期更新相关模型信息，为生成或选择合适的动物模型以适应不同的实验需求提供见解和参考。
Animal models play a crucial role in studying the pathogenesis of diseases, developing new drugs, identifying disease risk markers, and improving means of prevention and treatment. However, modeling diabetic kidney disease (DKD) has posed a challenge for scientists. Although numerous models have been successfully developed, none of them can encompass all the key characteristics of human DKD. It is essential to choose the appropriate model according to the research needs, as different models develop different phenotypes and have their limitations. This paper provides a comprehensive overview of biochemical and histological phenotypes, modeling mechanisms, advantages and limitations of DKD animal models, in order to update relevant model information and provide insights and references for generating or selecting the appropriate animal models to fit different experimental needs.
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影响因子：
4.6
作者：
Zhang C;Dower K;Zhang B;Martinez RV;Lin LL;Zhao S
通讯作者：
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影响因子：
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通讯作者：
Grineva EN
DOI：
10.1159/000327586
发表时间：
2011
期刊：
Nephron. Experimental nephrology
影响因子：
--
作者：
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通讯作者：
Epstein PN