Prediction of early recurrent myocardial ischemia and coronary reocclusion after successful thrombolysis: a qualitative and quantitative angiographic study.
Prediction of early recurrent myocardial ischemia and coronary reocclusion after successful thrombolysis: a qualitative and quantitative angiographic study.
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成功溶栓后早期复发性心肌缺血和冠状动脉再闭塞的预测：定性和定量血管造影研究。
DOI：
10.1016/0002-9149(89)90312-3
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Aronson,L
中科院分区：
文献类型：
--
作者：
Wall,TC;Mark,DB;Califf,RM;Collins,G;Burgess,R;Skelton,TN;Hinohara,T;Kong,DF;Mantell,S;Aronson,L
为了确定心肌梗死相关冠状动脉狭窄的定性和定量测量与成功溶栓后随后复发性缺血/再闭塞的相关性，对47例急性心肌梗死患者进行了研究，这些患者接受了6至8小时的高剂量（150 mg）组织型纤溶酶原激活剂治疗。无患者接受急诊冠状动脉成形术。所有患者在基线（90分钟）血管造影时均具有心肌梗死溶栓（TIMI）2级或更高血流; 31例患者还进行了24小时导管插入术。18例患者出现复发性缺血/再闭塞，而29例患者住院期间无事件。两组之间的基线临床特征无显著差异。在基线血管造影时，25例（86%）病程平稳的患者的TIMI血流为3级，而56%的复发性事件患者为3级。在基线导管插入时，两组之间的血管造影形态特征无显著差异。然而，在24小时时，随后发生复发事件的患者中没有一个有同心性狭窄，而其中13个（58%）有复杂的形态。相比之下，基线和24小时时的最小管腔直径、面积狭窄百分比和直径狭窄百分比的定量参数在有和没有复发性缺血/再闭塞的患者之间没有显著差异。这些结果表明，基线导管插入时冠状动脉血流的程度和质量是持续通畅和无事件住院的更重要的决定因素，而不是定量尺寸或冠状动脉形态。此外，在最初的24小时内未能成为同心圆的双翅更可能与随后的缺血或早期梗死周围期的再闭塞有关。
To determine the association of qualitative and quantitative measurements of the myocardial infarct-related coronary narrowing with subsequent recurrent ischemia/reocclusion after successful thrombolysis, 47 patients treated with high-dose (150 mg) tissue plasminogen activator over 6 to 8 hours were studied in the setting of acute myocardial infarction. No patient underwent emergent coronary angioplasty. All patients had Thrombolysis in Myocardial Infarction (TIMI) grade 2 flow or higher at the baseline (90-minute) angiogram; 31 patients had a protocol 24-hour catheterization as well. Eighteen patients had recurrent ischemia/reocclusion whereas 29 had an uneventful hospital course. There was no significant difference in baseline clinical characteristics between the 2 groups. Twenty-five (86%) of those with an uneventful course had TIMI grade 3 flow at baseline angiogram compared with 56% of patients with recurrent events. No significant difference in angiographic morphologic characteristics was found between the 2 groups at baseline catheterization. At 24 hours, however, none of the patients who subsequently had recurrent events had a concentric narrowing, while 13 (58%) of them had a complex morphology. In contrast, quantitative parameters of minimal lumen diameter, percent area stenosis and percent diameter stenosis at baseline and 24 hours were not significantly different between those who did and did not have recurrent ischemia/reocclusion. These findings suggest that the degree and quality of coronary flow at baseline catheterization are more important determinants of sustained patency and event-free hospitalization than are quantitative dimensions or coronary morphology. In addition, narrowings that fail to become concentric within the first 24 hours are more likely to be associated with subsequent ischemia or reocclusion during the early periinfarct period.
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影响因子：
37.8
作者：
H. Gold;R. Leinbach;H. Garabedian;Tsunehiro Yasuda;Jennifer A. Johns;ELLIOrT B. Grossbard;Igor F. Palacios;DEISIRE'COLLEN
通讯作者：
H. Gold;R. Leinbach;H. Garabedian;Tsunehiro Yasuda;Jennifer A. Johns;ELLIOrT B. Grossbard;Igor F. Palacios;DEISIRE'COLLEN
链激酶再灌注后再血栓形成：残留病灶几何形状的重要性。
影响因子：
37.8
作者：
D. Harrison;D. Ferguson;S. M. Collins;D. Skorton;E. Ericksen;J. Michael;Kioschos;M. D..;M. Marcus;C. White
通讯作者：
C. White
DOI：
10.1016/s0735-1097(86)80455-7
发表时间：
1986-03-01
影响因子：
24
作者：
AMBROSE, JA;WINTERS, SL;FUSTER, V
通讯作者：
FUSTER, V
影响因子：
4.8
作者：
RIDOLFI, RL;HUTCHINS, GM
通讯作者：
HUTCHINS, GM
数字血管造影对切除、灌注心脏中正常冠状动脉腔段进行定量的准确性。
DOI：
10.1016/0002-9149(87)90901-5
发表时间：
1987
期刊：
The American journal of cardiology
影响因子：
--
作者：
Skelton,TN;Kisslo,KB;Mikat,EM;Bashore,TM
通讯作者：
Bashore,TM