Neurodevelopmental consequences of sub-clinical carbon monoxide exposure in newborn mice.
Neurodevelopmental consequences of sub-clinical carbon monoxide exposure in newborn mice.
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DOI：
10.1371/journal.pone.0032029
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Levy RJ
中科院分区：
文献类型：
--
作者：
Cheng Y;Thomas A;Mardini F;Bianchi SL;Tang JX;Peng J;Wei H;Eckenhoff MF;Eckenhoff RG;Levy RJ
Carbon monoxide (CO) exposure at high concentrations results in overt neurotoxicity. Exposure to low CO concentrations occurs commonly yet is usually sub-clinical. Infants are uniquely vulnerable to a variety of toxins, however, the effects of postnatal sub-clinical CO exposure on the developing brain are unknown. Apoptosis occurs normally within the brain during development and is critical for synaptogenesis. Here we demonstrate that brief, postnatal sub-clinical CO exposure inhibits developmental neuroapoptosis resulting in impaired learning, memory, and social behavior. Three hour exposure to 5 ppm or 100 ppm CO impaired cytochrome c release, caspase-3 activation, and apoptosis in neocortex and hippocampus of 10 day old CD-1 mice. CO increased NeuN protein, neuronal numbers, and resulted in megalencephaly. CO-exposed mice demonstrated impaired memory and learning and reduced socialization following exposure. Thus, CO-mediated inhibition of neuroapoptosis might represent an important etiology of acquired neurocognitive impairment and behavioral disorders in children.
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影响因子：
10.4
作者：
Eskenazi B;Castorina R
通讯作者：
Castorina R
影响因子：
3.8
作者：
Barnard-Brak, Lucy;Sulak, Tracey;Hatz, Julie K. Ivey
通讯作者：
Hatz, Julie K. Ivey
影响因子：
--
作者：
Amitai, Y;Zlotogorski, Z;Wexler, A
通讯作者：
Wexler, A
影响因子：
3.8
作者：
Bernardini, Chiara;Zannoni, Augusta;Forni, Monica
通讯作者：
Forni, Monica
影响因子：
4.1
作者：
Berger, RP;Adelson, PD;Kochanek, PM
通讯作者：
Kochanek, PM