Verbal Encoding Deficits in a Patient with a Left Retrosplenial Lesion
Verbal Encoding Deficits in a Patient with a Left Retrosplenial Lesion
复制标题
左侧脾后病变患者的语言编码缺陷
作者：
C. McDonald;B. Crosson;E. Valenstein;D. Bowers
在过去的十年中，与压后损伤相关的记忆障碍受到神经科学家越来越多的关注，尽管压后区域在记忆中的确切作用尚未明确定义。来自损伤研究和功能性神经影像学的证据表明，压后区参与言语情景记忆、信息的时间顺序和地形记忆。此外，最近的正电子发射断层扫描研究表明，在涉及编码和检索情节信息的任务中，压后皮层的激活增加。本研究的目的是更清楚地定义在压后遗忘症中观察到的记忆障碍的性质。一名47岁的健忘症男性与左压后动静脉畸形进行了检查的神经认知任务的自动和定向编码，时间顺序的信息，和远程记忆。尽管在额叶认知任务上表现正常，对远程信息的记忆完好，智商上级，但这个人在信息编码方面表现出严重的缺陷，表现为前摄干扰的释放不良，单词列表回忆的类别聚类不良，处理任务水平的语义编码不良，以及时间顺序的轻度损伤。这些结果意味着，压后区在言语编码的信息，这有助于深刻的言语记忆障碍与压后损伤的患者在以前的案例研究中报告的作用。
Over the past decade, memory impairments associated with retrosplenial damage have received increased attention among neuroscientists, although the exact role of the retrosplenial region in memory has not been clearly defined. Evidence from lesion studies and functional neuroimaging has implicated the retrosplenial region in verbal episodic memory, temporal ordering of information, and topographical memory. In addition, recent positron emission tomography studies have shown increased activation of the retrosplenial cortex during tasks involving both the encoding and retrieval of episodic information. The objective of this study was to define more clearly the nature of memory impairments observed in retrosplenial amnesia. A 47-year-old amnesic male with a left retrosplenial arteriovenous malformation was examined on neurocognitive tasks of automatic and directed encoding, temporal ordering of information, and remote memory. Despite normal performance on frontal cognitive tasks, intact memory for remote information, and a superior IQ, this individual exhibited a profound deficit in the encoding of information, evidenced by poor release from proactive interference, poor category clustering on word list recall, poor semantic encoding on a levels of processing task, and mild impairments in temporal ordering. These results imply that the retrosplenial region plays a role in the verbal encoding of information, which contributes to the profound verbal memory impairment reported in previous case studies of patients with retrosplenial damage.
不同形式健忘症的比较：某些缺陷是科萨科夫综合征所特有的。
DOI：
10.1037//0278-7393.8.6.560
发表时间：
1982
期刊：
Journal of experimental psychology. Learning, memory, and cognition
影响因子：
--
作者：
Squire,LR
通讯作者：
Squire,LR