Controlling histone methylation via trans-histone pathways.
Controlling histone methylation via trans-histone pathways.
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DOI：
10.4161/epi.3.5.6869
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发表时间：
2008-09
期刊：
影响因子：
3.7
通讯作者：
Briggs SD
中科院分区：
文献类型：
--
作者：
Fingerman IM;Du HN;Briggs SD
组蛋白的共价翻译后修饰已被证明参与广泛的细胞过程，包括基因转录的调节、基因阻遏、DNA双链断裂修复和有丝分裂。这些共价修饰的调控以及这种调控的影响目前引起了极大的兴趣。早已知道，这些染色质修饰的添加和/或去除由各种类型的染色质修饰酶催化，例如组蛋白乙酰转移酶/脱乙酰酶和组蛋白甲基转移酶/脱甲基酶。最近，已经证明这些修饰的添加或去除可以取决于来自相同组蛋白内的顺式或来自另一组蛋白的反式的其他现有修饰。第一个反式组蛋白调控事件是在S.酿酒酵母，并影响组蛋白赖氨酸甲基化。本文综述了近年来发现的组蛋白赖氨酸甲基化的调控机制--转组蛋白途径。
Covalent post-translational modifications of histones have been demonstrated to participate in a wide array of cellular processes, including regulation of gene transcription, gene repression, DNA double strand break repair and mitosis. Regulation of how these covalent modifications, and the implications of this regulation, are currently of great interest. It has been long known that the addition and/or removal of these chromatin modifications are catalyzed by various classes of chromatin modifying enzymes, such as histone acetyltransferases/deacetylases and histone methyltransferases/demethylases. More recently, it has been demonstrated that the addition or removal of these modifications can be dependant upon other existing modifications, both in cis, from within the same histone, or in trans, contributed from another histone. The first trans-histone regulatory event was observed in S. cerevisiae, and influenced histone lysine methylation. This review will give insight into and summarize newly identified trans-histone pathways as a regulatory mechanism for histone lysine methylation.
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