PGA: power calculator for case-control genetic association analyses.

PGA: power calculator for case-control genetic association analyses.
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PGA:病例对照遗传关联分析的功效计算器。

DOI:
10.1186/1471-2156-9-36
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发表时间:
2008-05-13
期刊:
影响因子:
2.9
通讯作者:
Chen, Bingshu E.
Chen, Bingshu E.
中科院分区:
生物学3区
文献类型:
--
作者:
Menashe, Idan;Rosenberg, Philip S.;Chen, Bingshu E.

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统计能力计算为遗传关联研究的设计和解释提供了信息,但很少有程序针对无关对象中单核苷酸多态(SNPs)的病例对照研究而定制。我们已经开发了“遗传关联分析能力”(Power for Genetic Association Analyses,PGA)程序包,其中包括算法和图形用户界面,用于在不同的遗传模型和研究约束下使用SNP或单倍型效应计算样本量和最小可检测风险。该软件考虑了连锁不平衡和统计多重比较。结果以图形或表格的形式显示,并且可以以标准文件格式打印或导出。PGA是用户友好的软件,可以促进候选基因的关联研究、精细图谱研究和全基因组扫描的决策。可从以下位置下载独立的可执行文件和MatLab工具箱:
Statistical power calculations inform the design and interpretation of genetic association studies, but few programs are tailored to case-control studies of single nucleotide polymorphisms (SNPs) in unrelated subjects. We have developed the "Power for Genetic Association analyses" (PGA) package which comprises algorithms and graphical user interfaces for sample size and minimum detectable risk calculations using SNP or haplotype effects under different genetic models and study constrains. The software accounts for linkage disequilibrium and statistical multiple comparisons. The results are presented in graphs or tables and can be printed or exported in standard file formats. PGA is user friendly software that can facilitate decision making for association studies of candidate genes, fine-mapping studies, and whole-genome scans. Stand-alone executable files and a Matlab toolbox are available for download at:
DOI: 10.1093/oxfordjournals.aje.a115530
发表时间: 1990-03-01
影响因子: 5
作者:
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通讯作者: GAIL, MH
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