PGA: power calculator for case-control genetic association analyses.
PGA: power calculator for case-control genetic association analyses.
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PGA:病例对照遗传关联分析的功效计算器。
DOI:
10.1186/1471-2156-9-36
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发表时间:
2008-05-13
期刊:
影响因子:
2.9
通讯作者:
Chen, Bingshu E.
中科院分区:
文献类型:
--
作者:
Menashe, Idan;Rosenberg, Philip S.;Chen, Bingshu E.
Statistical power calculations inform the design and interpretation of genetic association studies, but few programs are tailored to case-control studies of single nucleotide polymorphisms (SNPs) in unrelated subjects. We have developed the "Power for Genetic Association analyses" (PGA) package which comprises algorithms and graphical user interfaces for sample size and minimum detectable risk calculations using SNP or haplotype effects under different genetic models and study constrains. The software accounts for linkage disequilibrium and statistical multiple comparisons. The results are presented in graphs or tables and can be printed or exported in standard file formats. PGA is user friendly software that can facilitate decision making for association studies of candidate genes, fine-mapping studies, and whole-genome scans. Stand-alone executable files and a Matlab toolbox are available for download at:
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影响因子:
5
作者:
LUBIN, JH;GAIL, MH
通讯作者:
GAIL, MH
DOI:
10.1111/j.2517-6161.1995.tb02031.x
发表时间:
1995-01-01
影响因子:
5.8
作者:
BENJAMINI, Y;HOCHBERG, Y
通讯作者:
HOCHBERG, Y
影响因子:
30.8
作者:
Skol, AD;Scott, LJ;Boehnke, M
通讯作者:
Boehnke, M
影响因子:
30.8
作者:
Haiman, Christopher A.;Patterson, Nick;Reich, David
通讯作者:
Reich, David
影响因子:
2.1
作者:
Chen, Bingshu E.;Sakoda, Lori C.;Rosenberg, Philip S.
通讯作者:
Rosenberg, Philip S.