Kinetics of nanoparticle targeting by dissipative particle dynamics simulations.
Kinetics of nanoparticle targeting by dissipative particle dynamics simulations.
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DOI：
10.1021/bm900785c
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发表时间：
2009-11-09
影响因子：
6.2
通讯作者：
Dormidontova, Elena E.
中科院分区：
文献类型：
--
作者：
Djohari, Hadrian;Dormidontova, Elena E.
耗散粒子动力学模拟应用于研究纳米粒子靶向含有高浓度受体的细胞表面。我们发现，结合配体的归一化数目服从指数增长函数1 - exp（-t/τ），寿命τ随结合强度的增加而增加。随着结合能的增加，由于大量稳定结合的配体，其中大部分位于纳米颗粒外围，吸附的纳米颗粒的形状变成椭圆形。对于均匀分布的配体的低官能化程度，纳米颗粒附着的动力学由于非官能链的干扰而减慢，平衡时结合的配体的总数减少，尽管配体附着的稳定性增加。具有位于纳米颗粒一侧的功能化链的Janus样纳米颗粒表现出与细胞表面更快速的结合，具有大量平衡数量的稳定结合的配体。
Dissipative Particle Dynamics simulations are applied to study nanoparticle targeting to a cell surface containing a high concentration of receptors. We found that the normalized number of bound ligands follows an exponential growth function 1 - exp(-t/τ), with the lifetime τ increasing as a function of the binding strength. With increasing binding energy, the shape of the adsorbed nanoparticle becomes ellipsoidal due to a large number of stably bound ligands, most of which are positioned on the nanoparticle periphery. For a low degree of functionalization of homogeneously distributed ligands, the kinetics of nanoparticle attachment slows down due to interference by non-functional chains, the overall number of bound ligands at equilibrium decreases, although the stability of ligand attachment increases. Janus-like nanoparticles with functionalized chains positioned on one side of the nanoparticle exhibit more rapid binding to the cell surface with a large equilibrium number of stably bound ligands.
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DOI：
10.1021/la801935h
发表时间：
2008-11-18
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
Hagy MC;Wang S;Dormidontova EE
通讯作者：
Dormidontova EE
影响因子：
14
作者：
Decuzzi, Paolo;Ferrari, Mauro
通讯作者：
Ferrari, Mauro
影响因子：
38.3
作者：
Jiang, Wen;Kim, Betty Y. S.;Chan, Warren C. W.
通讯作者：
Chan, Warren C. W.
影响因子：
3.9
作者：
Chen, CC;Dormidontova, EE
通讯作者：
Dormidontova, EE
影响因子：
4
作者：
Carlson, Coby B.;Mowery, Patricia;Kiessling, Laura L.
通讯作者：
Kiessling, Laura L.