Cholecystectomy-induced secondary bile acids accumulation ameliorates colitis through inhibiting monocyte/macrophage recruitment.
Cholecystectomy-induced secondary bile acids accumulation ameliorates colitis through inhibiting monocyte/macrophage recruitment.
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胆囊切除术诱导的继发性胆汁酸蓄积通过抑制单核细胞/巨噬细胞募集改善结肠炎
DOI：
10.1080/19490976.2022.2107387
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发表时间：
2022-01
期刊：
影响因子：
12.2
通讯作者：
Liu, Yulan
中科院分区：
文献类型：
--
作者：
Liu, Yun;Xu, Jun;Ren, Xinhua;Zhang, Yu;Ke, Ziliang;Zhou, Jianhua;Wang, Yang;Zhang, Yifan;Liu, Yulan
Although post-cholecystectomy (PC) patients usually have gastrointestinal complications and a higher risk of colorectal cancer, previous studies undetected a heightened risk of inflammatory bowel disease. Thus, we tried to investigate cholecystectomy’s impact and pathophysiological mechanism on murine colitis models and clarify the association among fecal bile acids (BAs), mucosal bacterial microbiota, and immune cells in the PC patients. One month or three months after cholecystectomy, mice have induced colitis and tested BAs and fecal microbiota analysis. Next, mice were treated with various cholecystectomy-accumulated bile acids in drinking water for three months before inducing colitis. All 14 paired PC patients and healthy subjects were enrolled for BAs and mucosal microbiota analysis. Cholecystectomy ameliorated DSS-induced murine colitis, accelerated mucosal repair, and induced a significant shifting of fecal microbiota and BAs profiles under colitis status, which featured a higher relative abundance of species involved in BAs metabolism and increased secondary BAs concentrations. Cholecystectomy-associated secondary BAs (LCA, DCA, and HDCA) also ameliorated DSS-induced colitis and accelerated mucosal repair in mice. Cholecystectomy and specific secondary BAs treatments inhibited monocytes/macrophages recruitment in colitis mice. In vitro, cholecystectomy-associated secondary BAs also downregulated monocytes chemokines in the THP-1 derived macrophages through activation of the LXRα-linked signaling pathway. The alterations of mucosal microbiota and fecal BAs profiles were found in the PC patients, characterized as increased species with potential immuno-modulating effects and secondary BAs, which were negatively associated with peripheral monocytes levels. Cholecystectomy-induced secondary bile acids accumulation ameliorated colitis through inhibiting monocyte/macrophage recruitment, which might be mediated by the LXRα-related signaling pathway. Cholecystectomy, after 3 months follow-up, has an immune-regulatory role in murine colitis, preliminarily explaining that no increased risk of IBD had been reported in the PC patients, which still warrants further studies.
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影响因子：
4.6
作者：
De Marino S;Carino A;Masullo D;Finamore C;Marchianò S;Cipriani S;Di Leva FS;Catalanotti B;Novellino E;Limongelli V;Fiorucci S;Zampella A
通讯作者：
Zampella A
DOI：
10.1007/164_2019_238
发表时间：
2019-01-01
期刊：
BILE ACIDS AND THEIR RECEPTORS
影响因子：
--
作者：
Fiorucci, Stefano;Distrutti, Eleonora
通讯作者：
Distrutti, Eleonora
影响因子：
6.7
作者：
Amigo, Ludwig;Husche, Constanze;Nervi, Flavio
通讯作者：
Nervi, Flavio
肠道 LXRα 在调节餐后脂质激增和饮食诱发的高胆固醇血症及肝脏脂质积累中的作用
影响因子：
4
作者：
Benitez-Santana, Tibiabin;Hugo, Sarah E.;Schlegel, Amnon
通讯作者：
Schlegel, Amnon
影响因子：
8.7
作者：
Bain CC;Mowat AM
通讯作者：
Mowat AM