Macrophages in intestinal homeostasis and inflammation.
Macrophages in intestinal homeostasis and inflammation.
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DOI：
10.1111/imr.12192
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发表时间：
2014-07
影响因子：
8.7
通讯作者：
Mowat AM
中科院分区：
文献类型：
--
作者：
Bain CC;Mowat AM
肠道含有体内最大的巨噬细胞池，在面对微生物区系时，巨噬细胞对于维持粘膜的动态平衡和持续的上皮更新是必不可少的，但它也是保护性免疫的重要组成部分，参与炎症性肠病(IBD)的病理过程。然而，在确定粘膜中不同群体的髓系细胞的表型和来源方面的问题阻碍了对肠道巨噬细胞生物学作用的确定。在这里，我们讨论如何结合使用多个参数来区分功能不同的髓系细胞，并讨论巨噬细胞在动态平衡中的作用以及当炎症接踵而至时这些作用如何改变。我们还讨论了肠道巨噬细胞不符合当前范例的证据，即组织驻留巨噬细胞来自胚胎前体细胞，这些前体在原位自我更新，但需要单核细胞持续补充。我们描述了我们最近的工作，证明了经典单核细胞不断进入肠道粘膜，以及环境如何决定它们随后的命运。我们相信，了解推动肠道巨噬细胞稳定发育的因素以及这些因素如何在病原体或炎症反应中发生变化，可以为IBD的治疗提供重要的见解。
The intestine contains the largest pool of macrophages in the body which are essential for maintaining mucosal homeostasis in the face of the microbiota and the constant need for epithelial renewal but are also important components of protective immunity and are involved in the pathology of inflammatory bowel disease (IBD). However, defining the biological roles of intestinal macrophages has been impeded by problems in defining the phenotype and origins of different populations of myeloid cells in the mucosa. Here, we discuss how multiple parameters can be used in combination to discriminate between functionally distinct myeloid cells and discuss the roles of macrophages during homeostasis and how these may change when inflammation ensues. We also discuss the evidence that intestinal macrophages do not fit the current paradigm that tissue-resident macrophages are derived from embryonic precursors that self-renew in situ, but require constant replenishment by blood monocytes. We describe our recent work demonstrating that classical monocytes constantly enter the intestinal mucosa and how the environment dictates their subsequent fate. We believe that understanding the factors that drive intestinal macrophage development in the steady state and how these may change in response to pathogens or inflammation could provide important insights into the treatment of IBD.
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Langerhans细胞（LC）增殖介导了新生儿发育，体内平衡和与表皮LC网络的炎症相关扩张。
DOI：
10.1084/jem.20091586
发表时间：
2009-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chorro L;Sarde A;Li M;Woollard KJ;Chambon P;Malissen B;Kissenpfennig A;Barbaroux JB;Groves R;Geissmann F
通讯作者：
Geissmann F
影响因子：
2.8
作者：
Bradford, Barry M.;Sester, David P.;Mabbott, Neil A.
通讯作者：
Mabbott, Neil A.
影响因子：
20.3
作者：
Gautier, Emmanuel L.;Ivanov, Stoyan;Randolph, Gwendalyn J.
通讯作者：
Randolph, Gwendalyn J.
影响因子：
3.3
作者：
Chen, SZ;Luo, DF;Harrison, JK
通讯作者：
Harrison, JK
影响因子：
32.4
作者：
Farache J;Koren I;Milo I;Gurevich I;Kim KW;Zigmond E;Furtado GC;Lira SA;Shakhar G
通讯作者：
Shakhar G