Nerve root magnetic stimulation improves locomotor function following spinal cord injury with electrophysiological improvements and cortical synaptic reconstruction.
Nerve root magnetic stimulation improves locomotor function following spinal cord injury with electrophysiological improvements and cortical synaptic reconstruction.
复制标题
神经根磁刺激通过电生理改善和皮质突触重建改善脊髓损伤后的运动功能。
DOI：
10.4103/1673-5374.335161
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发表时间：
2022-09
影响因子：
6.1
通讯作者：
Xu DS
中科院分区：
文献类型：
--
作者：
Zheng Y;Zhao D;Xue DD;Mao YR;Cao LY;Zhang Y;Zhu GY;Yang Q;Xu DS
脊髓损伤后，通常有一些神经通路在脊髓中保持完整。这些残留的神经纤维很重要，因为它们可以用来重建神经回路，使运动功能。我们的小组以前设计了一种新的磁刺激方案，靶向运动皮层和脊髓神经根，导致慢性不完全脊髓损伤患者的运动功能显着改善。在这里，我们研究了如何神经根磁刺激有助于改善运动功能，使用大鼠模型的脊髓损伤。在T10处对大鼠进行手术以夹住脊髓;三天后，用靶向L5-L 6椎骨处的神经根的重复磁刺激（5 Hz，25个脉冲/串，20个脉冲串）处理大鼠。在三周的时间内，每周重复治疗五次。我们发现神经根磁刺激能改善损伤脊髓的运动功能，增强神经传导。此外，神经根磁刺激促进感觉运动皮层突触超微结构的恢复。总之，结果表明，神经根磁刺激可能是一种有效的，非侵入性的方法，用于动员残留的脊髓通路，以促进运动功能的恢复。
Following a spinal cord injury, there are usually a number of neural pathways that remain intact in the spinal cord. These residual nerve fibers are important, as they could be used to reconstruct the neural circuits that enable motor function. Our group previously designed a novel magnetic stimulation protocol, targeting the motor cortex and the spinal nerve roots, that led to significant improvements in locomotor function in patients with a chronic incomplete spinal cord injury. Here, we investigated how nerve root magnetic stimulation contributes to improved locomotor function using a rat model of spinal cord injury. Rats underwent surgery to clamp the spinal cord at T10; three days later, the rats were treated with repetitive magnetic stimulation (5 Hz, 25 pulses/train, 20 pulse trains) targeting the nerve roots at the L5–L6 vertebrae. The treatment was repeated five times a week over a period of three weeks. We found that the nerve root magnetic stimulation improved the locomotor function and enhanced nerve conduction in the injured spinal cord. In addition, the nerve root magnetic stimulation promoted the recovery of synaptic ultrastructure in the sensorimotor cortex. Overall, the results suggest that nerve root magnetic stimulation may be an effective, noninvasive method for mobilizing the residual spinal cord pathways to promote the recovery of locomotor function.
影响因子：
6.1
作者：
Zhang KX;Zhao JJ;Chai W;Chen JY
通讯作者：
Chen JY