Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination survey.
Thyroid hormones and electrocardiographic parameters: findings from the third national health and nutrition examination survey.
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DOI：
10.1371/journal.pone.0059489
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Guallar E
中科院分区：
文献类型：
--
作者：
Zhang Y;Post WS;Cheng A;Blasco-Colmenares E;Tomaselli GF;Guallar E
甲状腺状态的改变对心脏产生重大影响。甲状腺功能减退或亢进的个体在心电图上表现出各种变化。然而，人们对甲状腺激素水平在正常范围内的变化如何影响普通人群的心脏电活动知之甚少。我们对来自第三次全国健康和营养检查调查的5，990名男性和女性进行了横断面分析。血清总T4测定采用免疫法，TSH测定采用荧光法。我们将T4和TSH分为7组，截断值分别为加权人群分布的第5、20、40、60、80和95位。从标准12导联心电图测量心电图参数。我们发现男性血清总T4水平与心率之间呈正线性相关，男性和女性T4与PR间期之间呈U形相关。男性TSH水平与QRS间期呈正相关，女性TSH水平与QRS间期呈U型相关。甲状腺激素和校正QT或JT之间没有明显的分级关联，除了T4水平最高的男性似乎有较长的校正QT和JT，T4水平最低的男性似乎有较短的校正QT和JT。一般人群中甲状腺激素水平的变化，即使在正常范围内，也与各种ECG变化相关。
Altered thyroid status exerts a major effect on the heart. Individuals with hypo- or hyperthyroidism showed various changes in electrocardiograms. However, little is known about how variations in thyroid hormone levels within the normal range affect electrical activities of the heart in the general population. We conducted a cross-sectional analysis of 5,990 men and women from the Third National Health and Nutrition Examination Survey. Serum total T4 was measured by immunoassay and TSH was measured by chemiluminescent assay. We categorized T4 and TSH into 7 groups with cut-offs at the 5th, 20th, 40th, 60th, 80th, and 95th percentiles of the weighted population distribution. Electrocardiographic parameters were measured from the standard 12-lead electrocardiogram. We found a positive linear association between serum total T4 level and heart rate in men, and a U-shape association between T4 and PR interval in men and women. TSH level was positively associated with QRS interval in men, while a U-shape association between TSH and QRS was observed in women. No clear graded association between thyroid hormones and corrected QT or JT was found, except that men in the highest category of T4 levels appeared to have longer corrected QT and JT, and men in the lowest category of T4 appeared to have shorter corrected QT and JT. Variation in thyroid hormone levels in the general population, even within the normal range, was associated with various ECG changes.
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影响因子：
3.2
作者：
Chen, Jin-Long;Chiu, Hung-Wen;Chu, Woei-Chyn
通讯作者：
Chu, Woei-Chyn
影响因子：
120.7
作者：
Cappola, AR;Fried, LP;Ladenson, PW
通讯作者：
Ladenson, PW
影响因子：
5.7
作者：
Toft, AD;Boon, NA
通讯作者：
Boon, NA
影响因子：
2.8
作者：
SARMA, JSM;VENKATARAMAN, K;SINGH, BN
通讯作者：
SINGH, BN
影响因子：
6.6
作者：
Sawin, CT
通讯作者：
Sawin, CT