Microemboli are not associated with delirium after coronary artery bypass graft surgery.
Microemboli are not associated with delirium after coronary artery bypass graft surgery.
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DOI：
10.1177/0267659109358207
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Marcantonio ER
中科院分区：
文献类型：
--
作者：
Rudolph JL;Babikian VL;Treanor P;Pochay VE;Wigginton JB;Crittenden MD;Marcantonio ER
谵妄是冠状动脉旁路移植术（CABG）后常见的一种急性认知变化。来自斑块、空气或血栓的脑微栓子被假设为导致CABG后谵妄和认知能力下降。本研究的目的是确定脑微栓子和心脏手术后谵妄之间是否存在关联。非谵妄患者（n=68）进行了前瞻性入组，并进行术中监测大脑中动脉经颅多普勒（TCD）。保存TCD信号，并根据既定标准手动分析术后微栓子。术后，采用标准化成套检查评估患者是否出现谵妄。33例患者（48.5%）术后发生谵妄。在伴有和不伴有谵妄的患者中，微栓子计数（平均值± SD）无显著差异（303 ±449 vs. 299 ±350; p=0.97）。虽然术中微栓子与CABG后谵妄无关，但对微栓子来源和成分的进一步研究可进一步阐明微栓子的长期临床影响。
Delirium is an acute change in cognition which occurs frequently after coronary artery bypass graft (CABG) surgery. Cerebral microemboli, from plaque, air, or thrombus, have been hypothesized to contribute to delirium and cognitive decline after CABG. The purpose of this study was to determine if there was an association between cerebral microemboli and delirium after cardiac surgery. Non-delirious patients (n=68) were prospectively enrolled and underwent intraoperative monitoring of the middle cerebral arteries with transcranial Doppler (TCD). TCD signals were saved and analyzed postoperatively for microemboli manually, according to established criteria. Postoperatively, patients were assessed for delirium with a standardized battery. Thirty-three patients (48.5%) developed delirium after surgery. Microemboli counts (mean ± SD) were not significantly different in those with and without delirium (303 ±449 vs. 299 ±350; p=0.97). While intraoperative microemboli were not associated with delirium after CABG, further investigation into the source and composition of microemboli can further elucidate the long-term clinical impact of microemboli.
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影响因子：
5.9
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