Comprehensive Analysis of the Expression and Prognosis for Laminin Genes in Ovarian Cancer.
Comprehensive Analysis of the Expression and Prognosis for Laminin Genes in Ovarian Cancer.
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DOI：
10.3389/pore.2021.1609855
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Yang P
中科院分区：
文献类型：
--
作者：
Diao B;Yang P
卵巢癌 (OC) 的生存率较低。大多数 OC 患者表现出晚期转移，并且复发很常见。层粘连蛋白相互作用的失调与癌症的发展有关。然而，层粘连蛋白亚基是否可以作为 OC 诊断、预后和治疗的生物标志物尚不清楚。我们使用 cBioPortal、GEO、ONCOMINE、GEPIA、Human Protein Atlas、Kaplan-Meier Plotter、TIMER 和 Metascape 来确定 OC 中层粘连蛋白表达、预后和免疫细胞浸润之间的关联。与正常卵巢相比，OC 组织中 LAMA5、LAMB3 和 LAMC2 mRNA 以及 LAMA3、LAMB1/B2/B3 和 LAMC1/C2 蛋白过度表达。 LAMA4、LAMB1 和 LAMC1 mRNA 上调与 OC 中较差的总生存期 (OS) 和无进展生存期 (PFS) 呈正相关。 LAMA2 和 LAMC2 mRNA 表达水平升高分别与更好的 PFS 或 OS 相关。结果推测 LAMA5 可能是 OC 的良好预后因素。事实证明，其表达对于预测诊断为 IV 期和 3 级 OC 的患者的 OS 以及诊断为所有 OC 分期或级别的患者的 PFS 很有价值。 LAMB3 和 LAMC2 表达与铂耐药的发展相关。对 OC 组中层粘连蛋白的 ROC 分析表明，LAMA2/A4/A5、LAMB1/B2/B3 和 LAMC2 可用于区分恶性肿瘤和非肿瘤组织。 LAMA1/A5 和 LAMC1 与各种肿瘤免疫浸润 (TIL) 显着负相关，尤其是与树突状细胞、CD8+ T 细胞或中性粒细胞。 LAMA4 和 LAMB1 可能与 OC 中的肿瘤纯度相关。总体而言，LAMA5 和 LAMC1 可以帮助预测 OC 生存和诊断，并可能被视为重要的 OC 癌基因。
Survival is low in ovarian cancer (OC). Most OC patients demonstrate advanced metastases, and recurrence is common. Dysregulation of laminin interactions is associated with cancer development. However, it is unknown whether laminin subunits can be considered as biomarkers for OC diagnosis, prognosis, and treatment. We used cBioPortal, GEO, ONCOMINE, GEPIA, Human Protein Atlas, Kaplan-Meier Plotter, TIMER, and Metascape to determine the associations among laminin expression, prognosis, and immune cell infiltration in OC. LAMA5, LAMB3, and LAMC2 mRNAs and LAMA3, LAMB1/B2/B3, and LAMC1/C2 proteins were overexpressed in OC tissues compared with normal ovaries. LAMA4, LAMB1, and LAMC1 mRNA upregulation was positively correlated with worse overall survival (OS) and progression-free survival (PFS) in OC. Elevated LAMA2 and LAMC2 mRNA expression levels were related to better PFS or OS, respectively. The results speculated that LAMA5 could potentially be a good prognostic factor in OC. Its expression proves valuable for predicting OS in patients diagnosed with stage Ⅳ and grade 3 OC and PFS in patients diagnosed with all OC stages or grades. LAMB3 and LAMC2 expression was correlated with platinum resistance development. ROC analysis of laminins in OC sets revealed that LAMA2/A4/A5, LAMB1/B2/B3, and LAMC2 could be used to differentiate between malignant tumors and non-neoplastic tissues. LAMA1/A5 and LAMC1 were significantly and negatively correlated with various tumor immune infiltrates (TILs), especially with dendritic cells, CD8+ T cells or neutrophil. LAMA4 and LAMB1 might be associated with tumor purity in OC. Overall, LAMA5 and LAMC1 could help predict OC survival and diagnosis and might be deemed important OC oncogenes.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
3.8
作者：
Arrighetti, Noemi;Cossa, Giacomo;Gatti, Laura
通讯作者：
Gatti, Laura
影响因子：
5
作者：
Shkurnikov, Maxim;Nikulin, Sergey;Tonevitsky, Alexander
通讯作者：
Tonevitsky, Alexander
影响因子：
3.8
作者：
Meyniel, Jean-Philippe;Cottu, Paul H;Sastre-Garau, Xavier
通讯作者：
Sastre-Garau, Xavier
影响因子：
50.5
作者：
Krzystyniak, J.;Ceppi, L.;Birrer, M. J.
通讯作者：
Birrer, M. J.