Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: a review.
Mass spectrometry techniques in the survey of steroid metabolites as potential disease biomarkers: a review.
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DOI：
10.1016/j.metabol.2013.04.003
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发表时间：
2013-09
影响因子：
9.8
通讯作者：
Vale, Nuno
中科院分区：
文献类型：
--
作者：
Gouveia, Maria Joao;Brindley, Paul J.;Santos, Lucio Lara;Correia da Costa, Jose Manuel;Gomes, Paula;Vale, Nuno
质谱方法已基本的类固醇激素相关的代谢物的鉴定，但这一主题还没有在最近几年进行了深入的审查。为此，并考虑到越来越多的相关性的液相色谱-质谱（LC-MS）研究类固醇激素及其代谢产物，本审查解决了这个问题。本综述及时总结了在一系列人类疾病环境中评价甾体生物标志物期间使用各种基于质谱的分析技术。这些技术的敏感性和特异性显然为乳腺癌和心血管疾病提供了有价值的新见解。我们的目标是促进对类固醇代谢的深入了解，以及如何通过LC-MS技术进行分析。
Mass spectrometric approaches have been fundamental to the identification of metabolites associated with steroid hormones, yet this topic has not been reviewed in depth in recent years. To this end, and given the increasing relevance of liquid chromatrography-mass spectrometry (LC-MS) studies on steroid hormones and their metabolites, the present review addresses this subject. This review provides a timely summary of the use of various mass spectrometry-based analytical techniques during the evaluation of steroidal biomarkers in a range of human disease settings. The sensitivity and specificity of these technologies are clearly providing valuable new insights into breast cancer and cardiovascular disease. We aim to contribute to an enhanced understanding of steroid metabolism and how it can be profiled by LC-MS techniques.
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影响因子：
2.1
作者：
Botelho, M. C.;Crespo, M.;Correia da Costa, J. M.
通讯作者：
Correia da Costa, J. M.
影响因子：
7.4
作者：
Chatman, K;Hollenbeck, T;Siuzdak, G
通讯作者：
Siuzdak, G
影响因子：
2.7
作者：
Goto, T;Shibata, A;Goto, J
通讯作者：
Goto, J
DOI：
10.1158/1055-9965.epi-09-0591
发表时间：
2009-11
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Eliassen AH;Ziegler RG;Rosner B;Veenstra TD;Roman JM;Xu X;Hankinson SE
通讯作者：
Hankinson SE
DOI：
10.1158/1055-9965.epi-08-0355
发表时间：
2008-12
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Falk RT;Xu X;Keefer L;Veenstra TD;Ziegler RG
通讯作者：
Ziegler RG