QTc interval prolongation, inflammation, and mortality in patients with COVID-19.
QTc interval prolongation, inflammation, and mortality in patients with COVID-19.
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DOI：
10.1007/s10840-021-01033-8
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Vergara P
中科院分区：
文献类型：
--
作者：
Gulletta S;Della Bella P;Pannone L;Falasconi G;Cianfanelli L;Altizio S;Cinel E;Da Prat V;Napolano A;D'Angelo G;Brugliera L;Agricola E;Landoni G;Tresoldi M;Rovere PQ;Ciceri F;Zangrillo A;Vergara P
全身性炎症与校正的QT间期延长有关。探讨炎症因素在新冠肺炎患者QTcs延长中的作用。纳入了2020年3月14日至2020年3月30日期间在IRCCS San Raffaele科学研究所(意大利米兰)接受实验室确认的SARS-CoV-2感染的患者。QTC-I按Bazett公式定义为住院期间、新药物治疗前第一次心电图的QTC间期，QTC-II为羟氯喹药物治疗开始后的QT间期。QTC-I延长45例(45%)，正常55例(55%)。QTC-I较长的患者年龄较大，男性较多。长QTC-I和长QTC-II患者入院时C反应蛋白(CRP)和白细胞(WBC)计数均较高。QTC-I与入院时的CRP水平显著相关。中位随访83天后，14名患者(14%)死亡。没有人死于室性心律失常。长QTC-I和长QTC-II患者的生存期分别比正常的QTC-I和QTC-II患者短。在COX多因素分析中，年龄(HR = 1.1，CI 95%1.04~1.18，p = 0.002)和心电图II时C反应蛋白(HR 1.1，CI 95%1.0~1.1，p = 0.02)是死亡的独立预测因素。入院时QTC是新冠肺炎患者死亡风险的简单危险标志物，反映心肌炎症状态。
Systemic inflammation has been associated with corrected QT (QTc) interval prolongation. The role of inflammation on QTc prolongation in COVID-19 patients was investigated. Patients with a laboratory-confirmed SARS-CoV-2 infection admitted to IRCCS San Raffaele Scientific Institute (Milan, Italy) between March 14, 2020, and March 30, 2020 were included. QTc-I was defined as the QTc interval by Bazett formula in the first ECG performed during the hospitalization, before any new drug treatment; QTc-II was the QTc in the ECG performed after the initiation of hydroxychloroquine drug treatment. QTc-I was long in 45 patients (45%) and normal in 55 patients (55%). Patients with long QTc-I were older and more frequently males. C-Reactive protein (CRP) and white blood cell (WBC) count at hospitalization were higher in patients with long QTc-I and long QTc-II. QTc-I was significantly correlated with CRP levels at hospitalization. After a median follow-up of 83 days, 14 patients (14%) died. There were no deaths attributed to ventricular arrhythmias. Patients with long QTc-I and long QTc-II had a shorter survival, compared with normal QTc-I and QTc-II patients, respectively. In Cox multivariate analysis, independent predictors of mortality were age (HR = 1.1, CI 95% 1.04–1.18, p = 0.002) and CRP at ECG II (HR 1.1, CI 95% 1.0–1.1, p = 0.02). QTc at hospitalization is a simple risk marker of mortality risk in COVID-19 patients and reflects the myocardial inflammatory status.
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DOI：
10.11909/j.issn.1671-5411.2016.09.013
发表时间：
2016-09
期刊：
Journal of geriatric cardiology : JGC
影响因子：
--
作者：
Rabkin SW;Cheng XJ;Thompson DJ
通讯作者：
Thompson DJ
影响因子：
158.5
作者：
Cavalcanti, A. B.;Zampieri, F. G.;Berwanger, O.
通讯作者：
Berwanger, O.
影响因子：
6.1
作者：
Babapoor-Farrokhran, Savalan;Gill, Deanna;Amanullah, Aman
通讯作者：
Amanullah, Aman
影响因子：
8.4
作者：
Lazzerini, Pietro Enea;Acampa, Maurizio;Capecchi, Pier Leopoldo
通讯作者：
Capecchi, Pier Leopoldo
影响因子：
3.9
作者：
Farré N;Mojón D;Llagostera M;Belarte-Tornero LC;Calvo-Fernández A;Vallés E;Negrete A;García-Guimaraes M;Bartolomé Y;Fernández C;García-Duran AB;Marrugat J;Vaquerizo B
通讯作者：
Vaquerizo B