Detailed analysis of the impact of age on the QT interval.
Detailed analysis of the impact of age on the QT interval.
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DOI：
10.11909/j.issn.1671-5411.2016.09.013
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Thompson DJ
中科院分区：
文献类型：
--
作者：
Rabkin SW;Cheng XJ;Thompson DJ
分析年龄对心电图QT间期的影响，QT间期是心血管死亡率和药物性心律失常的重要预测因子，并确定QT心率校正公式（QTc）是否与年龄和性别存在差异。数据来自美国国家健康和营养调查（NHANES）II和III，年龄在25至90岁的平民人口。计算所有年龄段的QT加权平均值和标准差。采用Bazett（QTcBZT）、Fridericia（QTcFRD）、Hodges（QTcHDG）、Dmitrienko（QTcDMT）、Rautaharju（QTcRTHa）和Frachol（QTcFRM）提出的6种QTc评价QTc。除女性的QTcBZT外，所有处方的QTc均与年龄和性别密切相关。QTc与年龄之间的关系是显著的，无论该关系是通过线性还是非线性（二次或三次样条）模型近似。男性的QTc随着年龄的增长而急剧增加。对于男性和女性，每个QTc公式的QTc方差与年龄之间存在显著（P < 0.001）正相关。年龄越大，尤其是80岁及以上，QTc越长的个体比例越大。QTc及其方差随年龄增长而增加。QTc间期延长在老年人中更常见，尤其是男性。
To analyze the effect of age on the ECG QT interval, an important predictor of cardiovascular mortality and drug-induced cardiac arrhythmias, and determine whether QT-heart rate correction formulae (QTc) have differential relationships with age and sex. Data were examined from the US National Health and Nutrition Examination Survey (NHANES) II and III, civilian population aged 25 to 90 years. QT weighted means and standard deviations were calculated for all ages. The QTc were evaluated for six QTc: proposed by Bazett (QTcBZT), Fridericia (QTcFRD), Hodges (QTcHDG), Dmitrienko (QTcDMT), Rautaharju (QTcRTHa) and Framingham (QTcFRM). QTc was strongly related to age and gender, for all formulae except for QTcBZT for women. The relationship between QTc and age was significant regardless of whether the relationship was approximated by a linear or non-linear (quadratic or cubic spline) model. QTc increased more dramatically with age in men. There was a significant (P < 0.001) positive relationship between QTc variance and age for each QTc formula for both men and women. There were a greater proportion of individuals with longer QTc with older ages especially age 80 years and above. QTc and its variance increase with age. Prolonged QTc is more prevalent in older individuals, especially men.
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影响因子：
2.6
作者：
Astrom-Lilja, Cecilia;Odeberg, Johanna Mercke;Hagg, Staffan
通讯作者：
Hagg, Staffan
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影响因子：
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作者：
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通讯作者：
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15.9
作者：
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通讯作者：
Adams, W
DOI：
10.1152/ajpregu.00352.2006
发表时间：
2007-02-01
影响因子：
2.8
作者：
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通讯作者：
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影响因子：
2.8
作者：
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通讯作者：
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