Cardiometabolic and renal phenotypes and transitions in the United States population
Cardiometabolic and renal phenotypes and transitions in the United States population
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DOI：
10.1038/s44161-023-00391-y
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发表时间：
2023-12-15
期刊：
影响因子：
--
通讯作者：
Ezzati M
中科院分区：
文献类型：
--
作者：
Lhoste VP;Zhou B;Mishra A;Bennett JE;Filippi S;Asaria P;Gregg EW;Danaei G;Ezzati M
心血管和肾脏疾病有共同的和不同的决定因素。在这项研究中，我们将无监督聚类应用于1988年至2018年的多轮国家健康和营养检查调查，并确定了10种心脏代谢和肾脏表型。这些包括一个“低风险”表型;两组具有平均风险因素水平但身高不同;一组体重指数低，高密度脂蛋白胆固醇水平高;五种表型具有一种或两种相关风险因素的高水平（“高心率”、“高胆固醇”、“高血压”、“严重肥胖”和“严重高血糖”）;和一种具有低舒张压（DBP）和低估计肾小球滤过率（eGFR）的表型。随着时间的推移，“高血压”和“高胆固醇”表型的患病率下降，而“严重肥胖”和“低DBP，低eGFR”表型的患病率上升。美国人群的心脏代谢和肾脏特征已从高血压和高胆固醇表型向肾功能差、高血糖和严重肥胖转变。
Cardiovascular and renal conditions have both shared and distinct determinants. In this study, we applied unsupervised clustering to multiple rounds of the National Health and Nutrition Examination Survey from 1988 to 2018, and identified 10 cardiometabolic and renal phenotypes. These included a ‘low risk’ phenotype; two groups with average risk factor levels but different heights; one group with low body-mass index and high levels of high-density lipoprotein cholesterol; five phenotypes with high levels of one or two related risk factors (‘high heart rate’, ‘high cholesterol’, ‘high blood pressure’, ‘severe obesity’ and ‘severe hyperglycemia’); and one phenotype with low diastolic blood pressure (DBP) and low estimated glomerular filtration rate (eGFR). Prevalence of the ‘high blood pressure’ and ‘high cholesterol’ phenotypes decreased over time, contrasted by a rise in the ‘severe obesity’ and ‘low DBP, low eGFR’ phenotypes. The cardiometabolic and renal traits of the US population have shifted from phenotypes with high blood pressure and cholesterol toward poor kidney function, hyperglycemia and severe obesity.
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影响因子：
4.3
作者：
Alhasoun F;Aleissa F;Alhazzani M;Moyano LG;Pinhanez C;González MC
通讯作者：
González MC
英国生物银行常见疾病中可遗传解释的多重发病率的全球概述。
影响因子：
12.3
作者：
Dong G;Feng J;Sun F;Chen J;Zhao XM
通讯作者：
Zhao XM
影响因子：
37.8
作者：
Angell SY;McConnell MV;Anderson CAM;Bibbins-Domingo K;Boyle DS;Capewell S;Ezzati M;de Ferranti S;Gaskin DJ;Goetzel RZ;Huffman MD;Jones M;Khan YM;Kim S;Kumanyika SK;McCray AT;Merritt RK;Milstein B;Mozaffarian D;Norris T;Roth GA;Sacco RL;Saucedo JF;Shay CM;Siedzik D;Saha S;Warner JJ
通讯作者：
Warner JJ
DOI：
10.1016/j.lanepe.2021.100047
发表时间：
2021-04
期刊：
The Lancet regional health. Europe
影响因子：
--
作者：
Bisquera A;Gulliford M;Dodhia H;Ledwaba-Chapman L;Durbaba S;Soley-Bori M;Fox-Rushby J;Ashworth M;Wang Y
通讯作者：
Wang Y
影响因子：
120.7
作者：
Carroll, Margaret D.;Kit, Brian K.;Mussolino, Michael E.
通讯作者：
Mussolino, Michael E.