The adipose organ at a glance.
The adipose organ at a glance.
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DOI：
10.1242/dmm.009662
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发表时间：
2012-09
影响因子：
4.3
通讯作者：
Cinti S
中科院分区：
文献类型：
--
作者：
Cinti S
脂肪器官的主要实质细胞是脂肪细胞。白色脂肪细胞储存能量，而棕色脂肪细胞消耗能量用于产热。这两种功能相反的细胞类型都可以起源于内皮细胞，并共存于脂肪器官的多个脂肪库中——我认为这一特征对这个器官的可塑性至关重要。这篇海报综述提供了脂肪器官的概述，描述了肥胖的解剖、细胞学、生理功能和组织病理学。它还强调了脂肪器官的显著可塑性，解释了在慢性寒冷暴露、体育锻炼或哺乳以及肥胖期间脂肪细胞转分化的理论。白色到棕色脂肪细胞的转分化具有特殊的医学意义，因为动物数据表明，较高数量的棕色脂肪组织与抵抗肥胖及其合并症呈正相关，脂肪器官的“褐化”抑制了这些疾病。
The main parenchymal cells of the adipose organ are adipocytes. White adipocytes store energy, whereas brown adipocytes dissipate energy for thermogenesis. These two cell types with opposing functions can both originate from endothelial cells, and co-exist in the multiple fat depots of the adipose organ – a feature that I propose is crucial for this organ’s plasticity. This poster review provides an overview of the adipose organ, describing its anatomy, cytology, physiological function and histopathology in obesity. It also highlights the remarkable plasticity of the adipose organ, explaining theories of adipocyte transdifferentiation during chronic cold exposure, physical exercise or lactation, as well as in obesity. White-to-brown adipocyte transdifferentiation is of particular medical relevance, because animal data indicate that higher amounts of brown adipose tissue are positively associated with resistance to obesity and its co-morbidities, and that ‘browning’ of the adipose organ curbs these disorders.
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DOI：
10.1097/med.0b013e328337a81f
发表时间：
2010-04
期刊：
Current opinion in endocrinology, diabetes, and obesity
影响因子：
--
作者：
Cypess AM;Kahn CR
通讯作者：
Kahn CR
影响因子：
15.9
作者：
Crossno, Joseph T., Jr.;Majka, Susan M.;Klemm, Dwight J.
通讯作者：
Klemm, Dwight J.
影响因子：
2.7
作者：
Atit, Radhika;Sgaier, Sema K.;Conlon, Ronald A.
通讯作者：
Conlon, Ronald A.
影响因子：
4.8
作者：
Cinti, S;Frederich, RC;Lowell, BB
通讯作者：
Lowell, BB
影响因子：
4.9
作者：
De Matteis, R;Petroni, ML;Stock, MJ
通讯作者：
Stock, MJ