IgG expression in human colorectal cancer and its relationship to cancer cell behaviors.
IgG expression in human colorectal cancer and its relationship to cancer cell behaviors.
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人结直肠癌中 IgG 的表达及其与癌细胞行为的关系
DOI：
10.1371/journal.pone.0047362
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Gu J
中科院分区：
文献类型：
--
作者：
Niu N;Zhang J;Huang T;Sun Y;Chen Z;Yi W;Korteweg C;Wang J;Gu J
越来越多的证据表明，各种癌细胞类型都能够产生IgG。然而，癌症来源的IgG的确切功能尚未阐明。我们在80例大肠癌、4株大肠癌细胞系和一个荷瘤免疫缺陷小鼠模型中证实了V（D）J重组IgG基因的表达。IgG的表达与肿瘤分化程度、pTNM分期、淋巴结转移、炎症浸润有关，与Cyclin D1、NF-κB、PCNA的表达呈正相关。此外，我们研究了癌源性IgG对结直肠癌细胞恶性行为的影响，结果表明，阻断IgG导致细胞凋亡增加，并对锚定非依赖性集落形成和癌细胞侵袭的潜力产生负面影响。这些发现表明，由结直肠癌细胞合成的IgG参与结直肠癌的发展和生长，并且阻断IgG可能是治疗这种癌症的潜在疗法。
Increasing evidence indicates that various cancer cell types are capable of producing IgG. The exact function of cancer-derived IgG has, however, not been elucidated. Here we demonstrated the expression of IgG genes with V(D)J recombination in 80 cases of colorectal cancers, 4 colon cancer cell lines and a tumor bearing immune deficient mouse model. IgG expression was associated with tumor differentiation, pTNM stage, lymph node involvement and inflammatory infiltration and positively correlated with the expressions of Cyclin D1, NF-κB and PCNA. Furthermore, we investigated the effect of cancer-derived IgG on the malignant behaviors of colorectal cancer cells and showed that blockage of IgG resulted in increased apoptosis and negatively affected the potential for anchor-independent colony formation and cancer cell invasion. These findings suggest that IgG synthesized by colorectal cancer cells is involved in the development and growth of colorectal cancer and blockage of IgG may be a potential therapy in treating this cancer.
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影响因子：
24.5
作者：
DOE, WF
通讯作者：
DOE, WF
DOI：
10.1073/pnas.68.6.1372
发表时间：
1971-01-01
影响因子：
11.1
作者：
SJOGREN, HO;HELLSTROM, I;HELLSTROM, KE
通讯作者：
HELLSTROM, KE
影响因子：
3.6
作者：
Lee, Gregory;Laflamme, Emily;Ting, Hong Hoi
通讯作者：
Ting, Hong Hoi
影响因子：
5.8
作者：
Lee, Gregory;Zhu, Mingang;Potzold, Suzanne
通讯作者：
Potzold, Suzanne
影响因子：
5
作者：
Niu, Na;Zhang, Jie;Gu, Jiang
通讯作者：
Gu, Jiang