Cellular senescence and cancer: Focusing on traditional Chinese medicine and natural products.
Cellular senescence and cancer: Focusing on traditional Chinese medicine and natural products.
复制标题
细胞衰老与癌症：关注中药和天然产物。
DOI：
10.1111/cpr.12894
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发表时间：
2020-10
影响因子：
8.5
通讯作者：
Yu H
中科院分区：
文献类型：
--
作者：
Liu Y;Yang S;Wang K;Lu J;Bao X;Wang R;Qiu Y;Wang T;Yu H
癌症是人类死亡的主要原因，也是严重威胁人类生命的重要公共卫生问题。在治疗癌症的各种方法中，中药和天然产物以其高效、副作用小的独特优势，具有突出的抗癌效果。细胞衰老是由应激引发的细胞生长停滞的生理过程，是抵抗肿瘤发展的重要防线。近年来，中药活性成分和天然产物通过抑制端粒酶活性、引发DNA损伤、诱导SASP、激活或灭活癌基因等途径诱导细胞衰老，从而抑制肿瘤的发生和发展，成为研究热点。本文对近年来中药及天然产物中主要化合物通过诱导细胞衰老发挥抗癌作用的研究进展进行了系统综述，旨在为临床治疗促衰老肿瘤提供参考。作为一种重要的抗肿瘤功能，细胞衰老可以阻止受损DNA的细胞复制。细胞衰老通常由损伤刺激，例如端粒缩短、DNA损伤和癌基因诱导的衰老。中药活性成分及天然产物，通过抑制端粒酶活性，引发DNA损伤，诱导SASP，激活或灭活癌基因，诱导细胞衰老，从而抑制肿瘤的发生和发展。
Cancer is the principal cause of death and a dominant public health problem which seriously threatening human life. Among various ways to treat cancer, traditional Chinese medicine (TCM) and natural products have outstanding anti‐cancer effects with their unique advantages of high efficiency and minimal side effects. Cell senescence is a physiological process of cell growth stagnation triggered by stress, which is an important line of defence against tumour development. In recent years, active ingredients of TCM and natural products, as an interesting research hotspot, can induce cell senescence to suppress the occurrence and development of tumours, by inhibiting telomerase activity, triggering DNA damage, inducing SASP, and activating or inactivating oncogenes. In this paper, the recent research progress on the main compounds derived from TCM and natural products that play anti‐cancer roles by inducing cell senescence is systematically reviewed, aiming to provide a reference for the clinical treatment of pro‐senescent cancer. As an important anti‐tumour function, cell senescence could prevent the cellular replication of damaged DNA. Cell senescence is usually stimulated by damages, such as telomere shortening, DNA damage and oncogene‐induced senescence. Active ingredients of TCM and natural products, can induce cell senescence to suppress the occurrence and development of tumours, through inhibiting telomerase activity, triggering DNA damage, inducing SASP, and activating or inactivating oncogene.
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DOI：
10.1084/jem.20130783
发表时间：
2013-09-23
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Iannello A;Thompson TW;Ardolino M;Lowe SW;Raulet DH
通讯作者：
Raulet DH
影响因子：
3.8
作者：
ASAKAWA, Y;TOYOTA, M;TAKEMOTO, T
通讯作者：
TAKEMOTO, T
影响因子：
2
作者：
Chen, Jian;Huang, Xiaofei;Wu, Zhengzhi
通讯作者：
Wu, Zhengzhi
黄芩素和黄芩苷通过两种不同的细胞凋亡和衰老方式抑制结肠癌
影响因子：
--
作者：
Dou J;Wang Z;Ma L;Peng B;Mao K;Li C;Su M;Zhou C;Peng G
通讯作者：
Peng G
影响因子：
2.1
作者：
Li, Chenrui;Lin, Ge;Zuo, Zhong
通讯作者：
Zuo, Zhong