High-resolution phased-array MRI of the human brain at 7 tesla: initial experience in multiple sclerosis patients.
High-resolution phased-array MRI of the human brain at 7 tesla: initial experience in multiple sclerosis patients.
复制标题
DOI：
10.1111/j.1552-6569.2008.00338.x
复制
发表时间：
2010-04
期刊：
影响因子：
--
通讯作者：
Pelletier D
中科院分区：
文献类型：
--
作者：
Metcalf M;Xu D;Okuda DT;Carvajal L;Srinivasan R;Kelley DA;Mukherjee P;Nelson SJ;Vigneron DB;Pelletier D
磁共振成像（MRI）的最新进展涉及高场强的结合。虽然高磁场强度的成像仪已在研究实验室中开发和测试，但直接应用于患者核磁共振研究的情况非常有限。7特斯拉（7T）成像在信噪比、图像对比度和分辨率方面具有优势；然而，这些好处只能实现，如果有正确的线圈存在捕捉图像。本研究的目的是开发优化的高分辨率7T MRI技术，该技术使用高灵敏度，专用相控阵列线圈，用于改善灰质（GM）和白质分化，以提高体内多发性硬化症（MS）病变的可视化。本初步研究共纳入23名受试者，其中17名临床明确的MS患者（11名女性，6名男性，平均年龄43.4岁，年龄范围22-64岁），6名健康对照（2名女性，4名男性，平均年龄39.0岁，年龄范围27-67岁）。MS患者在7T时的MR成像被证明是安全的，耐受性良好，并提供高分辨率的解剖图像，可以可视化定位在皮层附近或内部的结构异常。与低场强成像相比，观察到GM明显受损伤，形态学细节得到改善。
Recent advancement for magnetic resonance imaging (MRI) involves the incorporation of higher-field strengths. Although imagers with higher magnetic field strengths were developed and tested in research labs, the direct application to patient MR studies have been extremely limited. Imaging at 7 Tesla (7T) affords advantages in signal-to-noise ratio and image contrast and resolution; however, these benefits can only be realized if the correct coils exist to capture the images. The objective of this study was to develop optimized high-resolution 7T MRI techniques using high sensitivity, specialized phased-array coils, for improved gray matter (GM) and white matter differentiation, in an effort to improve visualization of multiple sclerosis (MS) lesions in vivo. Twenty-three subjects were enrolled in this preliminary study, 17 with clinically definite MS (11 females, 6 males; mean age 43.4 years; range 22-64 years) and 6 healthy controls (2 females, 4 males; mean age 39.0 years; range 27-67 years). MR imaging of MS patients at 7T was demonstrated to be safe, well tolerated, and provided high-resolution anatomical images allowing visualization of structural abnormalities localized near or within the cortical layers. Clear involvement of the GM was observed with improved morphological detail in comparison to imaging at lower-field strength.
登录
查看更多内容
影响因子：
--
作者：
Bo, Lars;Geurts, Jeroen J. G.;Barkhof, Frederik
通讯作者：
Barkhof, Frederik
DOI：
10.1093/jnen/62.7.723
发表时间：
2003-07-01
影响因子：
3.2
作者：
Bo, L;Vedeler, CA;Mork, SJ
通讯作者：
Mork, SJ
影响因子：
3.3
作者：
Vaughan, Thomas;DelaBarre, Lance;Ugurbil, Kamil
通讯作者：
Ugurbil, Kamil
影响因子：
3.3
作者：
Vaughan, JT;Garwood, M;Ugurbil, K
通讯作者：
Ugurbil, K
影响因子：
3.3
作者：
Wiggins, GC;Potthast, A;Wald, LL
通讯作者：
Wald, LL