Effect of recombinant erythropoietin on anemia and orthostatic hypotension in primary autonomic failure
Effect of recombinant erythropoietin on anemia and orthostatic hypotension in primary autonomic failure
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重组促红细胞生成素对原发性自主神经衰竭贫血和体位性低血压的影响
DOI：
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发表时间：
1995
影响因子：
5.8
通讯作者：
H. Kaufmann
中科院分区：
文献类型：
--
作者：
R. Perera;L. Isola;H. Kaufmann
贫血是自主神经功能衰竭的常见并发症，红细胞质量减少可能导致这些患者的直立性低血压。我们研究了重组促红细胞生成素治疗原发性自主神经功能衰竭患者是否能改善贫血和升高血压。研究了3例多系统萎缩和自主神经功能衰竭患者和1例单纯自主神经功能衰竭患者。所有患者均患有正常红细胞正常色素性贫血和低（n = 2）或正常（n = 2）血清促红细胞生成素水平。用促红细胞生成素治疗，4000 U皮下注射，每两周一次，持续6周，所有患者的红细胞压积和血压均升高。红细胞压积从33.9 ± 0.7增加到44.3 ± 1.4%，仰卧位血压从150 ± 8/87 ± 8增加（收缩期/舒张期;平均值±标准差）至166 ± 25/92 ± 12 mmHg，在头高位倾斜3分钟后，从86 ± 21/47 ± 15至102 ± 23/63 ± 12 mmHg，（p < 0.05）。所有患者均报告直立症状改善，站立耐受性增加。这项研究表明，促红细胞生成素治疗可改善原发性自主神经功能衰竭患者的贫血、血压升高和直立性低血压。
Anemia is a common complication of autonomic failure and reduced red blood cell mass may contribute to the orthostatic hypotension of these patients. We investigated whether treatment with recombinant erythropoietin improves anemia and increases blood pressure in patients with primary autonomic failure. Three patients with multiple system atrophy and autonomic failure and one with pure autonomic failure were studied. All patients had normocytic normochromic anemia and low (n = 2) or normal (n = 2) serum levels of erythropoietin. Treatment with erythropoietin, 4000 U subcutaneously biweekly for 6 weeks, increased hematocrit and blood pressure in all patients. Hematocrit increased from 33.9 ± 0.7 to 44.3 ± 1.4%, blood pressure in supine position increased from 150 ± 8/87 ± 8 (systolic/diastolic; mean ± SD) to 166 ± 25/92 ± 12 mmHg, and after 3 min in the head-up tilt position from 86 ± 21/47 ± 15 to 102 ± 23/63 ± 12 mmHg, (p < 0.05). All patients reported improvement in orthostatic symptoms and increased tolerance to standing. The study shows that treatment with erythropoietin improves anemia, increases blood pressure and ameliorates orthostatic hypotension in patients with primary autonomic failure.
影响因子：
56.9
作者：
GOLDBERG, MA;DUNNING, SP;BUNN, HF
通讯作者：
BUNN, HF
DOI：
10.1073/pnas.87.15.5978
发表时间：
1990-08-01
影响因子：
11.1
作者：
ANAGNOSTOU, A;LEE, ES;STEINER, M
通讯作者：
STEINER, M