Plasminogen binding proteins and plasmin generation on the surface of Leptospira spp.: the contribution to the bacteria-host interactions.
Plasminogen binding proteins and plasmin generation on the surface of Leptospira spp.: the contribution to the bacteria-host interactions.
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DOI：
10.1155/2012/758513
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发表时间：
2012
影响因子：
--
通讯作者：
Nascimento AL
中科院分区：
文献类型：
--
作者：
Vieira ML;Atzingen MV;Oliveira R;Mendes RS;Domingos RF;Vasconcellos SA;Nascimento AL
钩端螺旋体病被认为是人类和兽医关注的一种被忽视的传染病。尽管几个研究小组对宿主和病原体的相互作用进行了广泛的研究，但致病性钩端螺旋体的感染、侵袭和持续机制仍然存在。仍有待阐明。我们已经报道了钩端螺旋体与人纤溶酶原(PLG)结合并在细菌表面产生酶活性纤溶酶(PLA)的能力。聚乳酸包被的钩端螺旋体可以降解固定化的细胞外基质分子，这一活性与宿主组织渗透有关。此外，我们还鉴定了几种可能作为PLG结合受体的蛋白质，每种蛋白质都能产生活性纤溶酶。钩端螺旋体外表面的聚乳酸活性可以通过在感染期间赋予细菌一些好处来阻碍宿主的免疫攻击。聚乳酸包被的钩端螺旋体很可能通过降解来阻止补体C3b和免疫球蛋白在细菌表面的沉积。钩端螺旋体调理作用的降低可能是免疫逃避策略的一个重要方面。我们认为，钩端螺旋体表面聚乳酸的存在可能(I)促进宿主组织的穿透，(Ii)帮助细菌逃避免疫系统，从而(Iii)允许钩端螺旋体到达继发性感染部位。
Leptospirosis is considered a neglected infectious disease of human and veterinary concern. Although extensive investigations on host-pathogen interactions have been pursued by several research groups, mechanisms of infection, invasion and persistence of pathogenic Leptospira spp. remain to be elucidated. We have reported the ability of leptospires to bind human plasminogen (PLG) and to generate enzimatically active plasmin (PLA) on the bacteria surface. PLA-coated Leptospira can degrade immobilized ECM molecules, an activity with implications in host tissue penetration. Moreover, we have identified and characterized several proteins that may act as PLG-binding receptors, each of them competent to generate active plasmin. The PLA activity associated to the outer surface of Leptospira could hamper the host immune attack by conferring the bacteria some benefit during infection. The PLA-coated leptospires obstruct complement C3b and IgG depositions on the bacterial surface, most probably through degradation. The decrease of leptospiral opsonization might be an important aspect of the immune evasion strategy. We believe that the presence of PLA on the leptospiral surface may (i) facilitate host tissue penetration, (ii) help the bacteria to evade the immune system and, as a consequence, (iii) permit Leptospira to reach secondary sites of infection.
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Pfam：氏族、网络工具和服务。
影响因子：
14.9
作者：
Finn, Robert D.;Mistry, Jaina;Schuster-Bockler, Benjamin;Griffiths-Jones, Sam;Hollich, Volker;Lassmann, Timo;Moxon, Simon;Marshall, Mhairi;Khanna, Ajay;Durbin, Richard;Eddy, Sean R.;Sonnhammer, Erik L. L.;Bateman, Alex
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影响因子：
3.1
作者：
Haake, DA;Chao, G;Bolin, CA
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影响因子：
3.1
作者：
Hauk, Pricila;Macedo, Felipe;Ho, Paulo Lee
通讯作者：
Ho, Paulo Lee
影响因子：
4.2
作者：
Atzingen MV;Barbosa AS;De Brito T;Vasconcellos SA;de Morais ZM;Lima DM;Abreu PA;Nascimento AL
通讯作者：
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影响因子：
64.5
作者：
Coleman, JL;Gebbia, JA;Benach, JL
通讯作者：
Benach, JL