An aromatase polymorphism modulates the relationship between weight and estradiol levels in obese men.
An aromatase polymorphism modulates the relationship between weight and estradiol levels in obese men.
复制标题
DOI：
10.1016/j.fertnstert.2009.10.037
复制
发表时间：
2010-10
影响因子：
6.7
通讯作者：
Gibson M
中科院分区：
文献类型：
--
作者：
Hammoud A;Carrell DT;Meikle AW;Xin Y;Hunt SC;Adams TD;Gibson M
目的：探讨TTTAn芳香酶基因多态性对肥胖男性肥胖与血浆雌二醇关系的影响。为期两年的队列研究。临床研究中心。严重肥胖的高加索男性(31名接受胃旁路手术，118名对照组)。对男性进行了TTTAn CYP19A1基因分型。在基线和两年的随访中，测定拟人化指标、血浆雌二醇和其他激素水平。研究体重、体重变化和血浆雌二醇与TTTAn基因多态的关系。平均年龄46.5±10.82岁，体重指数47.1±8.46 kg/m2。最常见的重复数为7和11。单因素分析显示，TTTAn数目与血浆雌二醇无关。当患者按体重分组时，只有在基线和两年内TTTA重复次数较高的男性中，才能看到血浆雌二醇与体重之间的相关性。同样，只有TTTA较高的男性在减肥后雌二醇水平降低。较高的TTTA重复数与肥胖和雌二醇之间的关系加强有关。在TTTA指数较低的男性中，体重增加对血浆雌二醇的影响似乎是不存在的。
To describe the influence of TTTAn aromatase polymorphism on the relation between obesity and plasma estradiol in obese men. A 2 years cohort study. Clinical research center. Severely obese Caucasian men (31 had gastric bypass surgery and 118 controls). Men were genotyped for the TTTAn CYP19A1 polymorphism. Anthropomorphic measures, plasma estradiol and other hormonal levels were determined at baseline and two years follow up. Relationships between weight and changes in weight and plasma estradiol were examined in relation to the TTTAn polymorphism. Mean age was 46.5 ± 10.82 years, and BMI was 47.1 ± 8.46 kg/m2. The most common repeats were 7 and 11. TTTAn number did not correlate to plasma estradiol in the univariate analysis. When patients were stratified per weight groups, the correlation between plasma estradiol and weight was seen only among men with higher TTTA repeat at baseline and two years. Similarly, only men with higher TTTA exhibited reduced estradiol levels after weight loss. Higher TTTA repeat are associated with a strengthened relationship between obesity and estradiol. The well established effect of increased weight on plasma estradiol appears to be absent in men with low TTTA numbers.
登录
查看更多内容
影响因子：
5.8
作者：
Masi, L;Becherini, L;Brandi, ML
通讯作者：
Brandi, ML
影响因子：
5.8
作者：
Hammoud, Ahmad;Gibson, Mark;Meikle, A. Wayne
通讯作者：
Meikle, A. Wayne
影响因子：
4.7
作者：
Healey, CS;Dunning, AM;Ponder, BAJ
通讯作者：
Ponder, BAJ
影响因子：
6.1
作者：
Kado, N;Kitawaki, J;Honjo, H
通讯作者：
Honjo, H
影响因子：
3.3
作者：
Kastelan, Darko;Grubic, Zorana;Korsic, Mirko
通讯作者：
Korsic, Mirko